{"id":"W4379878595","doi":"10.1038/s41556-023-01154-4","title":"Architecture and dynamics of a desmosome–endoplasmic reticulum complex","year":2023,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Pennsylvania State University; Northwestern University; Emory University; University of Pennsylvania; Gordon and Betty Moore Foundation; U.S. Department of Health and Human Services; National Institutes of Health; Keio University; Government of Canada; Penn State College of Medicine; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Howard Hughes Medical Institute","keywords":"Endoplasmic reticulum; Cell biology; Keratin; Intermediate filament; Desmosome; Cytoskeleton; Cytoplasm; Biology; Keratin 8; Cell junction; Chemistry; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001491311,0.0001705975,0.000203323,0.0003595003,0.0007989191,0.001002744,0.0003856718,0.000341291,0.001192588],"category_scores_gemma":[0.0003089964,0.0002848195,0.0001483299,0.0003462822,0.0003436705,0.001345837,0.0004655704,0.0004290538,0.0004983615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009455803,"about_ca_system_score_gemma":0.0003230217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001476509,"about_ca_topic_score_gemma":0.001414375,"domain_scores_codex":[0.9999251,0.000009632113,0.000005586689,0.00002666264,0.00001736676,0.00001551942],"domain_scores_gemma":[0.9998016,0.00003320737,0.00003846312,0.00002303652,0.00003729051,0.00006640693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003442557,0.00005698668,0.003595631,0.00009933612,0.00003568922,0.0003728718,0.0002313805,0.006213952,0.9668604,0.01620913,0.0005837317,0.005396623],"study_design_scores_gemma":[0.00007899934,0.0003221732,0.1002509,0.0000649014,0.00009586153,0.001504867,0.001111165,0.248535,0.6054833,0.013815,0.02856434,0.0001735411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904517,0.0009687177,0.005320161,0.0002859682,0.0000221506,0.00001058134,0.0001310492,0.00006979831,0.002739796],"genre_scores_gemma":[0.9957311,0.0003363407,0.002321064,0.00002835495,0.000008145536,0.000005930442,0.0001628514,0.00002075023,0.00138549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001476509,"threshold_uncertainty_score":0.006860733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007580881791888604,"score_gpt":0.2676489233854081,"score_spread":0.2600680415935195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}