{"id":"W4379878595","doi":"10.1038/s41556-023-01154-4","title":"Architecture and dynamics of a desmosome–endoplasmic reticulum complex","year":2023,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Pennsylvania State University; Northwestern University; Emory University; University of Pennsylvania; Gordon and Betty Moore Foundation; U.S. Department of Health and Human Services; National Institutes of Health; Keio University; Government of Canada; Penn State College of Medicine; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Howard Hughes Medical Institute","keywords":"Endoplasmic reticulum; Cell biology; Keratin; Intermediate filament; Desmosome; Cytoskeleton; Cytoplasm; Biology; Keratin 8; Cell junction; Chemistry; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002299616,0.000167713,0.0002248025,0.000123533,0.0000645484,0.000005665981,0.0002571152,0.0008651237,0.00004567032],"category_scores_gemma":[0.0001158116,0.0001389838,0.00008294467,0.0002373231,0.0004423939,8.966259e-7,0.0002791712,0.0004302116,0.00001682791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006330688,"about_ca_system_score_gemma":0.00004776769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008373771,"about_ca_topic_score_gemma":0.00005111507,"domain_scores_codex":[0.9987988,0.0001517702,0.0001781395,0.0004322162,0.00006890295,0.000370198],"domain_scores_gemma":[0.999391,0.00006090696,0.00006906949,0.0003228099,0.00007509605,0.0000811057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001081576,0.00002938273,0.0136522,0.00004711458,0.00004606032,0.0000145538,0.00002095519,0.000009252253,0.9812781,0.0007386189,0.001622244,0.002433363],"study_design_scores_gemma":[0.001629269,0.001163031,0.008501079,0.00001631462,0.00003355742,0.0002291285,0.0001938303,0.0009881668,0.8912081,0.002527737,0.0930341,0.0004756516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940565,0.001900717,0.0001622979,0.0004516017,0.0001746183,0.0001760436,0.0001219843,0.00002423561,0.002931988],"genre_scores_gemma":[0.9954347,0.0008496137,0.0004190692,0.0001730859,0.0001093348,0.0000123543,0.002135113,0.00001989328,0.0008468378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09141186,"threshold_uncertainty_score":0.6672626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007580881791888604,"score_gpt":0.2676489233854081,"score_spread":0.2600680415935195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}