{"id":"W4379878663","doi":"10.1038/s41592-023-01896-x","title":"Hardwiring tissue-specific AAV transduction in mice through engineered receptor expression","year":2023,"lang":"en","type":"article","venue":"Nature Methods","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Eye Institute; National Institute on Aging; Canadian Institutes of Health Research; Burroughs Wellcome Fund; International Retinal Research Foundation; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; BrightFocus Foundation; Office of Academic Affiliations, Department of Veterans Affairs; California Institute for Regenerative Medicine; Research to Prevent Blindness; Chemistry, Engineering and Medicine for Human Health, Stanford University; Li Ka Shing Foundation; U.S. Department of Veterans Affairs; Milky Way Research Foundation; Government of Canada; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Transduction (biophysics); Transgene; Biology; Adeno-associated virus; Cell biology; Genetically modified mouse; Signal transduction; Gene delivery; Cell type; Cell; Gene; Genetic enhancement; Genetics; Vector (molecular biology); Recombinant DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000700839,0.0008957923,0.0004747151,0.0009631471,0.000302898,0.0008370632,0.000757097,0.0008448915,0.002580191],"category_scores_gemma":[0.0002732755,0.0006269902,0.0007314709,0.0002669585,0.0007139436,0.0005750851,0.00081247,0.00169649,0.001190656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003570108,"about_ca_system_score_gemma":0.0005187223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005789141,"about_ca_topic_score_gemma":0.001084595,"domain_scores_codex":[0.9994234,0.00007560276,0.00007147789,0.0001601526,0.0001663093,0.0001030279],"domain_scores_gemma":[0.9995964,0.00007074469,0.0001416431,0.00007436676,0.00003209643,0.00008480753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002462174,0.00002237738,0.00004217479,0.00003973708,0.000008361482,0.0000412597,0.00001853467,0.0001466869,0.9963566,0.0008285248,0.0001003335,0.002370838],"study_design_scores_gemma":[0.00003578625,0.0004235713,0.0004960775,0.00003084132,0.00003232593,0.0005206806,0.00001966687,0.001798658,0.9824544,0.0003815284,0.01379198,0.00001446248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5689888,0.004378729,0.4056671,0.000937572,0.0007202194,0.001152267,0.001703866,0.004689707,0.0117617],"genre_scores_gemma":[0.7317109,0.007202324,0.2241271,0.0006187615,0.0001455422,0.001303968,0.002231384,0.001116341,0.03154361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002580191,"threshold_uncertainty_score":0.008631587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03497187557090128,"score_gpt":0.3999346048418897,"score_spread":0.3649627292709884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}