{"id":"W4379878663","doi":"10.1038/s41592-023-01896-x","title":"Hardwiring tissue-specific AAV transduction in mice through engineered receptor expression","year":2023,"lang":"en","type":"article","venue":"Nature Methods","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Eye Institute; National Institute on Aging; Canadian Institutes of Health Research; Burroughs Wellcome Fund; International Retinal Research Foundation; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; BrightFocus Foundation; Office of Academic Affiliations, Department of Veterans Affairs; California Institute for Regenerative Medicine; Research to Prevent Blindness; Chemistry, Engineering and Medicine for Human Health, Stanford University; Li Ka Shing Foundation; U.S. Department of Veterans Affairs; Milky Way Research Foundation; Government of Canada; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Transduction (biophysics); Transgene; Biology; Adeno-associated virus; Cell biology; Genetically modified mouse; Signal transduction; Gene delivery; Cell type; Cell; Gene; Genetic enhancement; Genetics; Vector (molecular biology); Recombinant DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001155317,0.0001698814,0.0001724302,0.0001342672,0.00006169442,0.00002103867,0.0002522169,0.0005407978,0.0001467061],"category_scores_gemma":[0.0001486795,0.0001632695,0.00007519274,0.0005853607,0.00003602792,0.000008423834,0.00005896851,0.0005826186,0.00003712934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003455262,"about_ca_system_score_gemma":0.0000354685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004605363,"about_ca_topic_score_gemma":0.0000132604,"domain_scores_codex":[0.9982727,0.0004998079,0.0001945242,0.0004734174,0.0002061294,0.000353423],"domain_scores_gemma":[0.9994242,0.00005714054,0.00003405289,0.0003652168,0.00006211596,0.00005724583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005584342,0.00002211182,0.00001285713,0.00002011973,0.00001319912,0.000003254225,0.0001869916,0.0002756046,0.9458678,0.00001135529,0.005066437,0.0479618],"study_design_scores_gemma":[0.0004031617,0.0002221911,0.0001329951,0.0000203981,0.00000200768,0.000002439151,0.0000582328,0.00003865623,0.7846509,0.00009167944,0.2142363,0.0001410884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9561064,0.01229782,0.02839363,0.0007385668,0.001253586,0.0004397366,0.00002290015,0.0001089523,0.0006383631],"genre_scores_gemma":[0.674037,0.006881131,0.3122065,0.0003198624,0.001844747,0.0001731921,0.000590855,0.000172182,0.003774483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2838129,"threshold_uncertainty_score":0.6657938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03497187557090128,"score_gpt":0.3999346048418897,"score_spread":0.3649627292709884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}