{"id":"W4379878813","doi":"10.1016/j.bmcl.2023.129371","title":"Amphiphilic tribasic galactosamines potentiate rifampicin in Gram-negative bacteria at low Mg++/Ca++concentrations","year":2023,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Amphiphile; Bacteria; Tobramycin; Acinetobacter baumannii; Rifampicin; Gram-negative bacteria; Antibiotics; Microbiology; Biochemistry; Escherichia coli; Pseudomonas aeruginosa; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001808973,0.0003572433,0.0003482143,0.0001516342,0.000108833,0.000222491,0.0001653326,0.0003321689,0.001561386],"category_scores_gemma":[0.0003824195,0.0001772332,0.0001768979,0.0001227546,0.0002712058,0.0001610605,0.0002876774,0.0003595343,0.0003939759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001413503,"about_ca_system_score_gemma":0.0001876093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000967009,"about_ca_topic_score_gemma":0.001579281,"domain_scores_codex":[0.9997608,0.00006345986,0.00002178874,0.000020841,0.00006206198,0.00007103875],"domain_scores_gemma":[0.9996872,0.00008836589,0.00006439684,0.00003276358,0.00003345206,0.0000938095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002896696,0.00001676494,0.00004645506,0.00003424294,0.000002309773,0.00002925054,0.00001430318,0.00002392506,0.9988306,0.00002384748,0.00002819911,0.0006604735],"study_design_scores_gemma":[0.00003254081,0.0006904155,0.002181566,0.000009253068,0.00000897991,0.00008887289,0.00002717728,0.0001837812,0.9958459,0.00001821104,0.0009084662,0.000004907379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946814,0.001661369,0.0006769627,0.0001247,0.00004536462,0.00003867407,0.0001596766,0.00007302647,0.002538703],"genre_scores_gemma":[0.9973085,0.0004830917,0.0005343083,0.00005980937,0.00001736795,0.00001485694,0.0001204052,0.00001661321,0.001445034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001561386,"threshold_uncertainty_score":0.005223334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008827058954648938,"score_gpt":0.2318682223355804,"score_spread":0.2230411633809315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}