{"id":"W4379879623","doi":"10.1016/j.neurobiolaging.2023.06.002","title":"Weak-hyperactive hippocampal CA1 neurons in the prodromal stage of Alzheimer's disease in hybrid AppNL-G-F/NL-G-F × Thy1-GCaMP6s+/− mice suggest disrupted plasticity","year":2023,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Lethbridge","funders":"Canadian Institutes of Health Research","keywords":"Hippocampal formation; Neuroscience; Psychology; Alzheimer's disease; Premovement neuronal activity; Hippocampus; Disease; Electrophysiology; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001301653,0.0005511165,0.0004618052,0.000819786,0.0003089327,0.0004575941,0.0003669254,0.0005885299,0.002414326],"category_scores_gemma":[0.0001735913,0.0003221133,0.0003363425,0.0002270564,0.0005998628,0.0004920665,0.0003435297,0.001437011,0.0005675109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002542342,"about_ca_system_score_gemma":0.0001771227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001406983,"about_ca_topic_score_gemma":0.002178076,"domain_scores_codex":[0.999863,0.000006217476,0.00001917221,0.00003578579,0.00003270565,0.0000431517],"domain_scores_gemma":[0.9996748,0.00002629619,0.00008463812,0.00002243872,0.0000326271,0.000159243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001927458,0.00002318255,0.0004679383,0.00001405818,0.00000584588,0.0002189754,0.00003406915,0.00001113017,0.9985846,0.00003505408,0.00002284691,0.0003895483],"study_design_scores_gemma":[0.00007052081,0.0004978075,0.1004448,0.00001693105,0.00007359817,0.005264152,0.0003671279,0.0004866071,0.8912747,0.0004289409,0.001052791,0.00002194206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971429,0.000523701,0.0008771016,0.00008264608,0.00003325741,0.00001185772,0.0004382087,0.00007352546,0.0008169106],"genre_scores_gemma":[0.9947311,0.0003316658,0.001005388,0.0000810276,0.00001196617,0.00003235571,0.0004063635,0.00005768657,0.003342435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002414326,"threshold_uncertainty_score":0.008076668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03240173913681667,"score_gpt":0.317261396447895,"score_spread":0.2848596573110784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}