{"id":"W4379966429","doi":"10.15252/embr.202356937","title":"LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity","year":2023,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"University of Toronto; Canadian Institutes of Health Research; Oregon Health and Science University","keywords":"Axon; Biology; Axon guidance; Phenotype; Neuroscience; Cell biology; Tyrosine kinase; Embryonic stem cell; Cell polarity; Kinase; Dendrite (mathematics); Signal transduction; Receptor; Cell; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002259588,0.0004985137,0.0002293311,0.0003303291,0.0003556111,0.000812842,0.0003659748,0.0004158847,0.004885691],"category_scores_gemma":[0.0002087186,0.0002184007,0.0004066341,0.0001926176,0.0005002486,0.0006195528,0.0004162647,0.00133617,0.001548764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009228851,"about_ca_system_score_gemma":0.000883627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001797281,"about_ca_topic_score_gemma":0.004578107,"domain_scores_codex":[0.9998347,0.00001575407,0.00001798509,0.00002427708,0.00003143045,0.00007577545],"domain_scores_gemma":[0.9998838,0.00001798477,0.00003184611,0.00001239868,0.00001175925,0.00004215353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001589215,0.0001779559,0.0005768671,0.0001469894,0.00002748024,0.0001281005,0.00003783271,0.0003416915,0.9888912,0.001384164,0.0006141752,0.00608436],"study_design_scores_gemma":[0.0002101684,0.0003952624,0.003040199,0.00001276171,0.00004104454,0.0001728259,0.000108988,0.001359357,0.9877365,0.0002492008,0.006658471,0.0000151379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844106,0.002583055,0.003363221,0.0008835693,0.0002600861,0.000047693,0.0010244,0.0003001007,0.007127266],"genre_scores_gemma":[0.9902272,0.001021469,0.001891313,0.0001134584,0.00003352034,0.00005098963,0.0007175705,0.0000422958,0.005902096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004885691,"threshold_uncertainty_score":0.01634431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03205334775439981,"score_gpt":0.2796217009524213,"score_spread":0.2475683531980215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}