{"id":"W4379966429","doi":"10.15252/embr.202356937","title":"LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity","year":2023,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"University of Toronto; Canadian Institutes of Health Research; Oregon Health and Science University","keywords":"Axon; Biology; Axon guidance; Phenotype; Neuroscience; Cell biology; Tyrosine kinase; Embryonic stem cell; Cell polarity; Kinase; Dendrite (mathematics); Signal transduction; Receptor; Cell; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003704896,0.000132127,0.0001509795,0.00004839068,0.0003101797,0.0000898237,0.00003602118,0.00006070124,0.00001129543],"category_scores_gemma":[0.0008871287,0.0001273484,0.00002906013,0.0002234867,0.0001135361,0.0002937935,0.0001188967,0.0002657161,0.000004968304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001198918,"about_ca_system_score_gemma":0.00003202867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005583735,"about_ca_topic_score_gemma":0.00001169825,"domain_scores_codex":[0.9984652,0.0001093131,0.0002527352,0.0005654217,0.0003271492,0.0002801651],"domain_scores_gemma":[0.9993805,0.0001976034,0.0001491932,0.000124277,0.00001812346,0.0001302496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001079692,0.0000276059,0.01330828,0.00001614933,0.000001259472,0.0004321162,0.00008596799,0.00000201411,0.982813,0.00004433686,0.0004018829,0.002856565],"study_design_scores_gemma":[0.0001595609,0.0001224685,0.138137,0.00003148085,0.00001237184,0.0008684589,0.00001480809,0.003171533,0.8537578,0.0007153488,0.00278554,0.0002235639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981349,0.00002865751,0.0000735353,0.0009442844,0.0001282596,0.0001825884,0.000006993227,0.0001519033,0.0003489521],"genre_scores_gemma":[0.9992543,0.00003945822,0.00002150351,0.0003908078,0.00006515228,0.000009025384,0.000003930532,0.00001653611,0.0001993247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1290552,"threshold_uncertainty_score":0.5193118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03205334775439981,"score_gpt":0.2796217009524213,"score_spread":0.2475683531980215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}