{"id":"W4379966658","doi":"10.1002/smll.202303007","title":"Nucleic Acid Enzyme‐Activated CRISPR‐Cas12a With Circular CRISPR RNA for Biosensing","year":2023,"lang":"en","type":"article","venue":"Small","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Fundamental Research Funds for the Central Universities; National Natural Science Foundation of China","keywords":"CRISPR; Trans-activating crRNA; Nucleic acid; RNA; DNA; Ribozyme; Deoxyribozyme; Biology; Computational biology; Cas9; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002059604,0.0002557051,0.0002430793,0.0001282898,0.0001855126,0.00004667817,0.0001615001,0.0002136122,0.000001530614],"category_scores_gemma":[0.0001102868,0.0002106247,0.0001708809,0.0003899016,0.0001091856,0.000005182522,0.00008227873,0.0001089723,0.0000107567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002284325,"about_ca_system_score_gemma":0.00005140086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001731979,"about_ca_topic_score_gemma":0.00003977751,"domain_scores_codex":[0.9985813,0.00004366346,0.0002257498,0.0005708133,0.000129759,0.0004487018],"domain_scores_gemma":[0.9990766,0.0000195234,0.0001166593,0.0004893883,0.0002006052,0.00009719714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001230487,0.00003093373,0.00009399765,0.00002782413,0.0001245076,0.00001874308,0.0000183157,0.00001737756,0.9935233,0.00002467671,0.002334263,0.003662998],"study_design_scores_gemma":[0.0004336433,0.0003343166,0.0001805712,0.0000352131,0.00007435919,0.00002443285,0.0001151804,0.0002575622,0.976553,0.000132646,0.02152055,0.0003385307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752438,0.0001878007,0.02271087,0.0005676609,0.00009520016,0.0003717745,0.00004336931,0.0003459845,0.0004335309],"genre_scores_gemma":[0.9870539,0.0001134437,0.01125106,0.0004159969,0.0002372136,0.00001696287,0.000326189,0.00006595045,0.0005192605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01918628,"threshold_uncertainty_score":0.8589026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01912628491050564,"score_gpt":0.2727656974451895,"score_spread":0.2536394125346838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}