{"id":"W4379967516","doi":"10.1007/s00417-023-06071-8","title":"Efficacy, durability, and safety of faricimab in patients from Asian countries with neovascular age-related macular degeneration: 1-Year subgroup analysis of the TENAYA and LUCERNE trials","year":2023,"lang":"en","type":"article","venue":"Graefe s Archive for Clinical and Experimental Ophthalmology","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"Genentech; F. Hoffmann-La Roche","keywords":"Aflibercept; Macular degeneration; Medicine; Clinical endpoint; Dosing; Subgroup analysis; Visual acuity; Ophthalmology; Clinical trial; Internal medicine; Adverse effect; Confidence interval; Bevacizumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004018898,0.0001487883,0.0009721986,0.0001052025,0.00006659016,0.000007388854,0.00005409145,0.00008666694,0.00003529185],"category_scores_gemma":[0.0001950916,0.00008606173,0.0003024676,0.0002475503,0.0007719573,0.00002515084,0.000112717,0.00008106888,4.335177e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001036018,"about_ca_system_score_gemma":0.00002279764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002922482,"about_ca_topic_score_gemma":0.00001147544,"domain_scores_codex":[0.9982443,0.0003197631,0.0007634746,0.0003648823,0.0001584761,0.0001491063],"domain_scores_gemma":[0.9988662,0.0006025843,0.0002050516,0.000206228,0.00003599685,0.00008391855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007731874,0.0006982886,0.988272,0.00003482176,0.001956726,0.0000417058,0.0003244166,0.000009258756,0.0002172768,0.0002621718,0.000005363422,0.0004461224],"study_design_scores_gemma":[0.01153778,0.001956281,0.9833193,0.00005014412,0.001493296,0.0000106349,0.0001984405,0.0002033059,0.0004391357,0.000692675,0.00001893613,0.00008006136],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975393,0.0008488322,0.000005309763,0.0001784916,0.00004716625,0.0009251057,0.00038524,0.000005739356,0.00006479817],"genre_scores_gemma":[0.998945,0.0001579353,0.0002177188,0.00002220621,0.00001047882,0.00003137279,0.0005864477,0.00001028001,0.00001857571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00495267,"threshold_uncertainty_score":0.3509496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04690455740078519,"score_gpt":0.3690412039576754,"score_spread":0.3221366465568902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}