{"id":"W4379967516","doi":"10.1007/s00417-023-06071-8","title":"Efficacy, durability, and safety of faricimab in patients from Asian countries with neovascular age-related macular degeneration: 1-Year subgroup analysis of the TENAYA and LUCERNE trials","year":2023,"lang":"en","type":"article","venue":"Graefe s Archive for Clinical and Experimental Ophthalmology","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"Genentech; F. Hoffmann-La Roche","keywords":"Aflibercept; Macular degeneration; Medicine; Clinical endpoint; Dosing; Subgroup analysis; Visual acuity; Ophthalmology; Clinical trial; Internal medicine; Adverse effect; Confidence interval; Bevacizumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008738955,0.001173902,0.004706128,0.0009521332,0.0004303294,0.001384584,0.0005752627,0.001174447,0.001219469],"category_scores_gemma":[0.006946403,0.0004805574,0.0114333,0.001375507,0.0004681227,0.000799762,0.0006091554,0.00125099,0.0001700554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005849688,"about_ca_system_score_gemma":0.0008056068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001168631,"about_ca_topic_score_gemma":0.003614706,"domain_scores_codex":[0.9950907,0.00268002,0.0009579138,0.0005628809,0.0003923994,0.000316019],"domain_scores_gemma":[0.9950716,0.002134444,0.001570259,0.0006017129,0.0003238799,0.0002980698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5816593,0.0005909544,0.1484561,0.007126413,0.196301,0.0005536921,0.0004096255,0.001353786,0.003514842,0.0002308869,0.001891494,0.057912],"study_design_scores_gemma":[0.2104439,0.03382366,0.4185913,0.001997791,0.3214644,0.001520755,0.0006897773,0.002479112,0.001981401,0.001082637,0.00569996,0.0002253439],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8818827,0.1126895,0.0008190259,0.000407397,0.0002981433,0.0005816806,0.001583268,0.00002628724,0.001712021],"genre_scores_gemma":[0.9899079,0.007350258,0.0002773401,0.0004209431,0.0002320638,0.0004265624,0.001099691,0.00001047944,0.0002747764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008738955,"threshold_uncertainty_score":0.04621655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04690455740078519,"score_gpt":0.3690412039576754,"score_spread":0.3221366465568902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}