{"id":"W4379967790","doi":"10.1002/mc.23585","title":"IL‐17 induces non‐small cell lung cancer metastasis via GCN5‐dependent SOX4 acetylation enhancing MMP9 gene transcription and expression","year":2023,"lang":"en","type":"article","venue":"Molecular Carcinogenesis","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Education and Child Care","funders":"","keywords":"Biology; Cancer research; SOX4; MMP9; Metastasis; Transcription factor; Lung cancer; Gene expression; Downregulation and upregulation; Promoter; Gene; Cancer; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003644291,0.0003287759,0.0002640942,0.0001576911,0.0002194323,0.00005826478,0.0001957088,0.0002803176,0.00003381657],"category_scores_gemma":[0.00001892397,0.0003359827,0.0001759382,0.0002557358,0.00004073673,0.00001323788,0.0001593553,0.0001184906,0.000009004637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003893895,"about_ca_system_score_gemma":0.00009047797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001521679,"about_ca_topic_score_gemma":0.00008315233,"domain_scores_codex":[0.99804,0.0001682954,0.0003190712,0.0007207447,0.0002930411,0.0004588694],"domain_scores_gemma":[0.9991685,0.00001135114,0.0001305271,0.0004076659,0.0001099181,0.0001720794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005342471,0.00002953073,0.00140231,0.0001453635,0.00007057453,0.00002430788,0.0003318338,0.0006756869,0.9935189,0.000001756078,0.0001337793,0.00361256],"study_design_scores_gemma":[0.0006318768,0.0001015523,0.00287559,0.00004086637,0.0001666755,0.00001078736,0.0001316523,0.0006431488,0.9945675,0.00001887832,0.0004194276,0.0003920914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9582486,0.006234418,0.03436206,0.0001012428,0.0001879374,0.0005424912,0.0001062654,0.00005526572,0.000161756],"genre_scores_gemma":[0.9959756,0.001120347,0.001488456,0.0002076982,0.0001779086,0.0002840306,0.0003306356,0.00007329784,0.0003420736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03772699,"threshold_uncertainty_score":0.9999092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01589857174495687,"score_gpt":0.2438626871768576,"score_spread":0.2279641154319007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}