{"id":"W4379979778","doi":"10.1002/hon.3166_ot15","title":"PHASE 1 STUDY OF PRT1419 (MCL1 INHIBITOR) AS MONOTHERAPY OR IN COMBINATION WITH AZACITIDINE OR VENETOCLAX IN PATIENTS WITH RELAPSED/REFRACTORY MYELOID OR B‐CELL MALIGNANCIES","year":2023,"lang":"en","type":"article","venue":"Hematological Oncology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Universitat Autònoma de Barcelona","keywords":"Venetoclax; Medicine; Azacitidine; Tolerability; Internal medicine; Myeloid leukemia; Oncology; Myeloid; Ven; Rituximab; Lymphoma; Cancer research; Leukemia; Chronic lymphocytic leukemia; Adverse effect; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005805842,0.0003304523,0.001281449,0.000649246,0.00005756556,0.000009910818,0.0002291842,0.0004033662,0.0004476748],"category_scores_gemma":[0.0005373114,0.0001699161,0.00004118725,0.001912658,0.000305434,0.0001314757,0.0001201523,0.0006991727,0.00006094797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001165101,"about_ca_system_score_gemma":0.001694188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001423013,"about_ca_topic_score_gemma":0.0007363322,"domain_scores_codex":[0.9967888,0.0004563947,0.0008306262,0.0006182049,0.0006643719,0.0006415777],"domain_scores_gemma":[0.9977878,0.001055573,0.0003133143,0.0003964318,0.0002637793,0.0001830639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2958754,0.05682054,0.6080506,0.0007186936,0.0002116415,0.01971126,0.005659556,0.000104843,0.003342412,0.0001967758,0.002268041,0.007040252],"study_design_scores_gemma":[0.2905625,0.4090038,0.2765482,0.0007333012,0.0001196575,0.0003954647,0.009546862,0.0006033352,0.007441129,0.000117397,0.004222658,0.0007056662],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955631,0.00003425996,0.00001193661,0.0004537564,0.00005694724,0.003330855,0.000009421539,0.0001062561,0.0004334954],"genre_scores_gemma":[0.9971293,0.0001063367,0.0004941656,0.0002898026,0.00002597172,0.0005615907,0.00007134011,0.00005168642,0.001269776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3521833,"threshold_uncertainty_score":0.6928976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03958954685764432,"score_gpt":0.3475295426058064,"score_spread":0.3079399957481621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}