{"id":"W4379981549","doi":"10.1016/s1569-1993(23)00332-6","title":"EPS5.02 Faecal microbiota changes in patients with cystic fibrosis with 6 months of elexacaftor/tezacaftor/ivacaftor: preliminary findings from the PROMISE study","year":2023,"lang":"en","type":"article","venue":"Journal of Cystic Fibrosis","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Calprotectin; Feces; Cystic fibrosis; Ivacaftor; Dysbiosis; Medicine; Biomarker; Microbiome; Gastroenterology; Gut flora; Internal medicine; Physiology; Immunology; Microbiology; Biology; Inflammatory bowel disease; Bioinformatics; Cystic fibrosis transmembrane conductance regulator; Disease; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004377121,0.0002601879,0.0005265097,0.0002199576,0.0003104225,0.0006486569,0.0001693355,0.0006107914,0.001258855],"category_scores_gemma":[0.00139956,0.0001519914,0.0005190248,0.000319519,0.0002309872,0.0005086251,0.0003148807,0.0006054449,0.00021982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000275372,"about_ca_system_score_gemma":0.0003543696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001366158,"about_ca_topic_score_gemma":0.001963506,"domain_scores_codex":[0.9996943,0.00007038867,0.00003498917,0.00007027056,0.00006668022,0.00006326483],"domain_scores_gemma":[0.9993315,0.0001319979,0.0002522512,0.00003289291,0.00007508753,0.0001763834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009514628,0.0007483705,0.9669427,0.0000913828,0.0002745049,0.0008616522,0.0002689648,0.00006412235,0.006261985,0.00003122202,0.0003628091,0.0145776],"study_design_scores_gemma":[0.0001639979,0.003460951,0.9934495,0.00002889911,0.0001975035,0.001165971,0.0004019228,0.000140777,0.0004621147,0.00003011464,0.0004870892,0.00001104082],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992403,0.0002629663,0.00003216866,0.00007764121,0.000009652284,0.000008164801,0.0001355435,0.000002184905,0.0002314044],"genre_scores_gemma":[0.9991571,0.0001496226,0.00008955915,0.00008976059,0.00001555532,0.00000934963,0.0002246431,0.00000186881,0.0002624882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001366158,"threshold_uncertainty_score":0.004211247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01095425623148896,"score_gpt":0.2623978441343013,"score_spread":0.2514435879028123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}