{"id":"W4379981851","doi":"10.1002/hon.3163_146","title":"IMMUNE CONTEXTURE ANALYSIS IN POLARIX SUGGESTS RESPONSE TO POLA‐R‐CHP TREATMENT REDUCES TUMOR MICROENVIRONMENT DEPENDENCY","year":2023,"lang":"en","type":"article","venue":"Hematological Oncology","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"International Prognostic Index; Rituximab; Vincristine; Medicine; Diffuse large B-cell lymphoma; Cyclophosphamide; Internal medicine; Prednisone; CHOP; Tumor microenvironment; Immune system; Lymphoma; Oncology; Hazard ratio; CD20; Gastroenterology; Cancer research; Immunology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004167918,0.0002351583,0.0003692576,0.0002395164,0.0002299226,0.0005348218,0.0002205359,0.0001906549,0.005149197],"category_scores_gemma":[0.0003702546,0.0001627319,0.0003122569,0.0002723898,0.0002803745,0.0002003345,0.0003417885,0.0004823426,0.0006130583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003844249,"about_ca_system_score_gemma":0.0003230966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001496481,"about_ca_topic_score_gemma":0.002088855,"domain_scores_codex":[0.9998252,0.00002544218,0.000006141428,0.00006691103,0.00004342336,0.00003290812],"domain_scores_gemma":[0.9998206,0.00004270492,0.00004951528,0.00001754984,0.00003402477,0.00003565806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02028047,0.0003030174,0.2906509,0.0004273269,0.0003343212,0.0003403648,0.0003439591,0.004620566,0.6190187,0.0004291459,0.006298554,0.05695273],"study_design_scores_gemma":[0.0008706917,0.003992438,0.7785061,0.00005668079,0.0005075799,0.001179242,0.000483743,0.01435082,0.1814017,0.0007087448,0.01789618,0.000046062],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884759,0.000733838,0.002174662,0.0001277756,0.00002846131,0.00004713256,0.005772074,0.0001800156,0.002460045],"genre_scores_gemma":[0.9882974,0.0002645121,0.001628356,0.0002195828,0.00001867152,0.00009539395,0.008208362,0.00005557577,0.001212314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005149197,"threshold_uncertainty_score":0.01722574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01990527309035667,"score_gpt":0.3052595588217014,"score_spread":0.2853542857313447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}