{"id":"W4379981917","doi":"10.1002/hon.3163_68","title":"BTG2 SUPER‐ENHANCER MUTATIONS DISRUPT TFAP4 BINDING AND DYSREGULATE BTG2 EXPRESSION IN DIFFUSE LARGE B‐CELL LYMPHOMA","year":2023,"lang":"en","type":"article","venue":"Hematological Oncology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Genome British Columbia","funders":"","keywords":"Biology; Diffuse large B-cell lymphoma; Somatic hypermutation; Enhancer; Cancer research; Gene; Genetics; Lymphoma; Transcription factor; B cell; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002584323,0.000223104,0.0003651502,0.000159975,0.0001477046,0.00002027414,0.0001444607,0.000630411,0.0000634548],"category_scores_gemma":[0.0001284163,0.0001957704,0.00008562664,0.0003780786,0.0001574646,0.00001136145,0.0002819659,0.0001288968,0.00008341276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009422186,"about_ca_system_score_gemma":0.00009138621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007228451,"about_ca_topic_score_gemma":0.0001079633,"domain_scores_codex":[0.9981409,0.0001875875,0.0004063346,0.0006039204,0.0001360781,0.0005252162],"domain_scores_gemma":[0.9993139,0.0001116261,0.0001245835,0.0002735594,0.00004434775,0.0001319669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002231626,0.001093416,0.008598512,0.00006426046,0.00002550597,0.0001294217,0.0003066397,0.0001651795,0.9817358,0.0002859203,0.002986573,0.004385672],"study_design_scores_gemma":[0.02055092,0.00117789,0.06046133,0.0001409635,0.00007525706,0.0004515018,0.001041191,0.004559886,0.8282645,0.001613661,0.08059651,0.001066436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968048,0.0007980137,0.0004219747,0.0005415402,0.0003079288,0.0003262976,0.00002648683,0.00007454439,0.0006984043],"genre_scores_gemma":[0.9973104,0.0005244295,0.0004295119,0.0001006152,0.0001036825,0.0001339606,0.0003569646,0.00002883107,0.001011616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1534713,"threshold_uncertainty_score":0.7983284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01385957703770127,"score_gpt":0.2959074096299436,"score_spread":0.2820478325922424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}