{"id":"W4379983442","doi":"10.1158/1538-7445.am2023-2658","title":"Abstract 2658: ZW251, a novel glypican-3-targeting antibody drug conjugate bearing a topoisomerase 1 inhibitor payload","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Glypican 3; Antibody; Flow cytometry; Cell culture; Immunoconjugate; Antibody-drug conjugate; Internalization; Molecular biology; Monoclonal antibody; Chemistry; Camptothecin; Cytotoxicity; Cancer research; Cell; In vitro; Biology; Hepatocellular carcinoma; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006491361,0.000467255,0.0001128427,0.0001693497,0.00007835215,0.0001355416,0.0002271386,0.0002309047,0.001289512],"category_scores_gemma":[0.00005397757,0.00006531429,0.0001104803,0.0001220349,0.00009745707,0.0001583236,0.0001224438,0.0002037955,0.0005162742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003164366,"about_ca_system_score_gemma":0.0001522432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005757731,"about_ca_topic_score_gemma":0.0004811342,"domain_scores_codex":[0.9999624,0.000005326186,0.000002493145,0.000009178475,0.00001170971,0.000008911528],"domain_scores_gemma":[0.9999843,0.000001259731,0.000005355018,8.894585e-7,0.000002499117,0.000005695116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000186028,0.00005039754,0.00013349,0.00007807385,0.0000114766,0.0001466938,0.00001443605,0.0003495938,0.9919747,0.0002520817,0.0004398853,0.006363227],"study_design_scores_gemma":[0.00007093196,0.0009870627,0.001559581,0.000008053584,0.00002772979,0.0006127516,0.00000951349,0.001275086,0.9868952,0.0000472868,0.008499247,0.000007548519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983817,0.003380244,0.005182039,0.0002046832,0.00006657098,0.0001159777,0.0004743467,0.000147212,0.006611919],"genre_scores_gemma":[0.9895839,0.001220483,0.002954957,0.00008663622,0.00001752476,0.000034372,0.0007158669,0.00001510156,0.005371117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001289512,"threshold_uncertainty_score":0.004313886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09549190664465584,"score_gpt":0.4433106334636574,"score_spread":0.3478187268190016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}