{"id":"W4379983662","doi":"10.1158/1538-7445.am2023-5661","title":"Abstract 5661: Pre-clinical development of a dopamine receptor 2, PD-1, and CD47 trispecific antibody for the treatment of solid tumors","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"","keywords":"CD47; Antibody; Lung cancer; Cancer; Cancer research; Medicine; Receptor; Antibody-dependent cell-mediated cytotoxicity; Dopamine receptor D2; Immunotherapy; Immunology; Internal medicine; Oncology; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006522724,0.0005843878,0.0003525564,0.0003479782,0.0002022642,0.000518848,0.0004288228,0.000637935,0.006271973],"category_scores_gemma":[0.0002447893,0.0002070535,0.0003769177,0.0001465641,0.0001987957,0.0003460741,0.0002653487,0.001476488,0.002241243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004859839,"about_ca_system_score_gemma":0.0009234551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007433511,"about_ca_topic_score_gemma":0.001220312,"domain_scores_codex":[0.9997806,0.00004270777,0.00001267155,0.00002637015,0.00007222338,0.00006546261],"domain_scores_gemma":[0.9998041,0.00001994492,0.00001926065,0.00001575391,0.00005375969,0.00008724054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002227911,0.004178962,0.00116813,0.000381013,0.00007610462,0.0003487651,0.00008164398,0.0009566263,0.8751265,0.001318953,0.009509142,0.1046261],"study_design_scores_gemma":[0.003352022,0.05122534,0.009289968,0.00009704877,0.0001645086,0.002405195,0.00005241953,0.002996961,0.8197939,0.0004037349,0.1101868,0.00003206668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.889559,0.01344674,0.02534193,0.003080189,0.001179062,0.004555397,0.003533073,0.00103487,0.05826974],"genre_scores_gemma":[0.9210597,0.007613339,0.0181132,0.001744316,0.0002250204,0.001617265,0.006115192,0.000118266,0.04339367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006271973,"threshold_uncertainty_score":0.02098191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.217038429220886,"score_gpt":0.5328918572125444,"score_spread":0.3158534279916584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}