{"id":"W4379984617","doi":"10.1002/alz.13318","title":"Longitudinal blood biomarker trajectories in preclinical Alzheimer's disease","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; Douglas Mental Health University Institute","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; HORIZON EUROPE Framework Programme; Olav Thon Stiftelsen; Vetenskapsrådet; UK Dementia Research Institute; EU Joint Programme – Neurodegenerative Disease Research; Familjen Erling-Perssons Stiftelse; Stiftelsen för Gamla Tjänarinnor; European Commission; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada; Hjärnfonden; Biogen; Alzheimer's Drug Discovery Foundation; Alzheimer's Association","keywords":"Glial fibrillary acidic protein; Apolipoprotein E; Biomarker; Internal medicine; Amyloid beta; Endocrinology; Medicine; Positron emission tomography; Alzheimer's disease; Amyloid (mycology); Cohort; Oncology; Psychology; Pathology; Disease; Chemistry; Nuclear medicine; Immunohistochemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0004708191,0.0004384974,0.0005465469,0.0004581205,0.0001863538,0.00007221037,0.000257706,0.0001442811,0.0009372335],"category_scores_gemma":[0.0001270729,0.0003886918,0.0003664583,0.001165102,0.0002834518,0.00022992,0.000227511,0.0003060443,0.001433635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001222523,"about_ca_system_score_gemma":0.0004597433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001525257,"about_ca_topic_score_gemma":0.00005692297,"domain_scores_codex":[0.996237,0.0001758642,0.00067406,0.0009091446,0.0009032895,0.001100653],"domain_scores_gemma":[0.9976305,0.0002164975,0.0001071189,0.0007868945,0.0001333983,0.001125638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001183018,0.001485008,0.8117487,0.00001752698,0.165014,0.003347243,0.00006511555,0.00000362475,0.00004833165,0.0001744575,0.005273406,0.01163949],"study_design_scores_gemma":[0.004222444,0.0003098479,0.9201632,0.00008877899,0.07224796,0.00002436579,0.00004405564,0.0002402425,0.0009386592,0.0004625844,0.0008875677,0.0003702716],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5999296,0.3938532,0.00000601316,0.001810228,0.0004752013,0.00166084,0.0001453601,0.0005059557,0.001613665],"genre_scores_gemma":[0.997491,0.0009029005,0.000237513,0.0001552231,0.0001998092,0.0003401763,0.000575153,0.00008438828,0.00001382369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3975615,"threshold_uncertainty_score":0.999976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09189019376463754,"score_gpt":0.3730535387263913,"score_spread":0.2811633449617538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}