{"id":"W4379984617","doi":"10.1002/alz.13318","title":"Longitudinal blood biomarker trajectories in preclinical Alzheimer's disease","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; Douglas Mental Health University Institute","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; HORIZON EUROPE Framework Programme; Olav Thon Stiftelsen; Vetenskapsrådet; UK Dementia Research Institute; EU Joint Programme – Neurodegenerative Disease Research; Familjen Erling-Perssons Stiftelse; Stiftelsen för Gamla Tjänarinnor; European Commission; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada; Hjärnfonden; Biogen; Alzheimer's Drug Discovery Foundation; Alzheimer's Association","keywords":"Glial fibrillary acidic protein; Apolipoprotein E; Biomarker; Internal medicine; Amyloid beta; Endocrinology; Medicine; Positron emission tomography; Alzheimer's disease; Amyloid (mycology); Cohort; Oncology; Psychology; Pathology; Disease; Chemistry; Nuclear medicine; Immunohistochemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006011883,0.0002391057,0.0002795204,0.0005549304,0.0003494847,0.0006494413,0.0002103633,0.0003881664,0.001074852],"category_scores_gemma":[0.001684724,0.0001591834,0.0002302352,0.0007530018,0.0001049375,0.0003847512,0.0003636974,0.0004058671,0.0002714544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002434489,"about_ca_system_score_gemma":0.000274468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005386253,"about_ca_topic_score_gemma":0.00440247,"domain_scores_codex":[0.9997707,0.00004950767,0.00001769152,0.00008751611,0.00003706888,0.00003759322],"domain_scores_gemma":[0.9992306,0.00009900749,0.0003173044,0.00005444277,0.0001804532,0.0001181309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002800646,0.00003547518,0.9955506,0.00001178271,0.00006592868,0.00008286291,0.0001017514,0.00008698812,0.0007569965,0.00004470941,0.0001659574,0.002816919],"study_design_scores_gemma":[0.000002749753,0.00008731206,0.9990941,0.000005132842,0.00002104562,0.0001084673,0.00006071357,0.0001561555,0.0001233589,0.00008537451,0.0002528803,0.000002674849],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978885,0.000515018,0.0002244187,0.00007526704,0.000007516622,0.000004855114,0.0008781409,0.000009873217,0.0003963459],"genre_scores_gemma":[0.9984068,0.0001720152,0.0001688921,0.00002251785,0.000007342398,0.000009032329,0.0008831864,0.000002531719,0.0003275158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005386253,"threshold_uncertainty_score":0.01070982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09189019376463754,"score_gpt":0.3730535387263913,"score_spread":0.2811633449617538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}