{"id":"W4379984937","doi":"10.1158/1538-7445.am2023-1837","title":"Abstract 1837: E7386, a selective inhibitor of the interaction between β-catenin and CREB-binding protein (CBP), enhances antitumor activity in combination with lenvatinib (LEN), and LEN + anti-PD-1 antibody in a preclinical tumor model","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nutrasource","funders":"","keywords":"Cancer research; Population; Medicine; Chemistry; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001297126,0.000473687,0.0005959623,0.0003911063,0.000158738,0.0001874532,0.0002324691,0.0003297721,0.002171485],"category_scores_gemma":[0.00005834493,0.0001263643,0.0002547347,0.0002912817,0.0002702928,0.0002322716,0.0001250848,0.0009171391,0.0003900104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002571287,"about_ca_system_score_gemma":0.000412049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008754223,"about_ca_topic_score_gemma":0.001583862,"domain_scores_codex":[0.9998351,0.00002915152,0.00001101815,0.00001911322,0.00004483302,0.00006075095],"domain_scores_gemma":[0.9999471,0.00000606608,0.00001167719,0.000004584598,0.000004253007,0.00002626939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005588776,0.003092595,0.0005148042,0.000130798,0.00005087112,0.0001043825,0.00002153329,0.0006122746,0.9764422,0.0001781321,0.0005417649,0.01272189],"study_design_scores_gemma":[0.001126814,0.01667723,0.004696731,0.000007588967,0.00009122673,0.000270617,0.00002995232,0.001951245,0.9720172,0.00004936674,0.003071245,0.00001071967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957326,0.0008384443,0.0006715207,0.0001167353,0.00004857748,0.0001014113,0.0003891192,0.0001080717,0.001993547],"genre_scores_gemma":[0.9955888,0.0005096793,0.0009699218,0.00005929213,0.00002040614,0.00007200449,0.0004770745,0.00001142469,0.002291429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002171485,"threshold_uncertainty_score":0.007264376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1683066051918371,"score_gpt":0.4923350120820459,"score_spread":0.3240284068902088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}