{"id":"W4379984948","doi":"10.1158/1538-7445.am2023-1558","title":"Abstract 1558: Targeting CDK9 via the small-molecule inhibitor enitociclib as a therapeutic strategy to treat <i>MYCN</i>-amplified rhabdomyosarcoma and neuroblastoma in children","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Neuroblastoma; Cancer research; Viability assay; Biology; Molecular biology; Apoptosis; Chemistry; Cell culture; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001065203,0.0003240494,0.0002877361,0.0001834886,0.00008089864,0.0002851289,0.0002782025,0.0001793774,0.001746287],"category_scores_gemma":[0.00005348108,0.00008270992,0.000174443,0.0001792379,0.0001207132,0.0001250727,0.0001311892,0.0005627786,0.0004331764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004990377,"about_ca_system_score_gemma":0.0004809868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001563848,"about_ca_topic_score_gemma":0.005377657,"domain_scores_codex":[0.9999515,0.000006326538,0.00000440274,0.00000936092,0.00001355549,0.00001480647],"domain_scores_gemma":[0.9999712,0.000002673395,0.000006678789,0.000001650257,0.000004265153,0.0000135658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002231185,0.0005177476,0.003688131,0.0004123838,0.00008088684,0.0005775694,0.00004420047,0.001087052,0.9378925,0.0005715879,0.002292143,0.05060463],"study_design_scores_gemma":[0.001235806,0.007946128,0.02022034,0.00006422769,0.0002157229,0.003208154,0.00007303057,0.002037219,0.9237471,0.00009166316,0.04113901,0.00002177683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9736825,0.01019388,0.001981007,0.0003785359,0.00008201339,0.0002530941,0.00241956,0.0001978704,0.01081153],"genre_scores_gemma":[0.9825576,0.00609085,0.003435259,0.0001800669,0.00001901446,0.0001337873,0.002651921,0.00002486242,0.004906679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001746287,"threshold_uncertainty_score":0.00584197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06213575915464956,"score_gpt":0.3880754105895953,"score_spread":0.3259396514349457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}