{"id":"W4379988364","doi":"10.1101/2023.06.08.544226","title":"<i>Acvr1b</i> loss increases formation of pancreatic precancerous lesions from acinar and ductal cells of origin","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Irving Medical Center, Columbia University; U.S. Department of Health and Human Services; National Institutes of Health; Michael Smith Health Research BC; Vanderbilt University","keywords":"KRAS; Pancreatic Intraepithelial Neoplasia; Pancreas; Intraductal papillary mucinous neoplasm; Pancreatic duct; Ductal cells; Pathology; Immunohistochemistry; Medicine; Acinar cell; Oncogene; Cancer research; Internal medicine; Cancer; Cell cycle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001976867,0.0004048179,0.0003767298,0.0004623049,0.0002101288,0.0006680128,0.0003640868,0.00075742,0.00676937],"category_scores_gemma":[0.0001743481,0.0003276993,0.0004592809,0.0002031511,0.0004921474,0.0004319005,0.0003025704,0.001485531,0.001694369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003811204,"about_ca_system_score_gemma":0.0002147184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009862694,"about_ca_topic_score_gemma":0.0008515859,"domain_scores_codex":[0.9995964,0.00005050426,0.00005631212,0.0001126866,0.00009110876,0.00009286612],"domain_scores_gemma":[0.9995994,0.00004059695,0.0001594296,0.00004395505,0.00002780747,0.0001289234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001939144,0.00003928422,0.0003027175,0.00005542637,0.00001077828,0.00006668205,0.00001301318,0.00004095878,0.9980918,0.0001395335,0.000178488,0.0008673386],"study_design_scores_gemma":[0.00004947183,0.0003814207,0.008807167,0.00002339167,0.00004656002,0.001158837,0.00009181183,0.0008311897,0.981672,0.0000943681,0.00683207,0.00001170496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829865,0.002729571,0.004850359,0.0007414951,0.0001453082,0.00005658964,0.00241683,0.0006817915,0.005391496],"genre_scores_gemma":[0.9877406,0.001029329,0.002106132,0.0002579107,0.00003100144,0.00006457565,0.001695076,0.0001782894,0.006897124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00676937,"threshold_uncertainty_score":0.02264577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03666943948224436,"score_gpt":0.2884645379146664,"score_spread":0.251795098432422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}