{"id":"W4380029463","doi":"10.1158/1538-7445.am2023-6362","title":"Abstract 6362: Overcoming resistance to immunotherapy due to loss of antigen presentation","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Cytotoxic T cell; Cancer research; Immune system; CD8; Immunotherapy; Melanoma; CD40; Immunology; Tumor microenvironment; Antigen presentation; Biology; T cell; Cancer immunotherapy; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001904743,0.0003944122,0.0004802137,0.0002294048,0.0001674862,0.0004916804,0.0002475891,0.0005763966,0.004239686],"category_scores_gemma":[0.0001530284,0.0001391192,0.000261924,0.0001480585,0.0001943862,0.0002550324,0.0002641215,0.0008446875,0.001508191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000207624,"about_ca_system_score_gemma":0.000218068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002679747,"about_ca_topic_score_gemma":0.0002530987,"domain_scores_codex":[0.9998098,0.00002034913,0.00001438141,0.00005028903,0.00005860121,0.00004652811],"domain_scores_gemma":[0.9999278,0.000007851437,0.0000171245,0.000008307049,0.00001294225,0.00002596881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001486861,0.00004290171,0.0001802956,0.00007583888,0.000006337775,0.00005799312,0.00001049496,0.00009744937,0.9944384,0.00009228267,0.0004726981,0.004376716],"study_design_scores_gemma":[0.0000973499,0.0009961796,0.004347573,0.00003595871,0.00004297543,0.0009377959,0.00003732111,0.002212233,0.9698768,0.0002863607,0.02111586,0.0000134785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9697953,0.009468115,0.01042978,0.001142498,0.0004615567,0.0001134685,0.001243071,0.0007644878,0.006581726],"genre_scores_gemma":[0.9766506,0.002411901,0.003914577,0.0006082315,0.00009016119,0.0001303486,0.001270905,0.0001663675,0.01475702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004239686,"threshold_uncertainty_score":0.01418316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.086722358174086,"score_gpt":0.4450993976130972,"score_spread":0.3583770394390112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}