{"id":"W4380029952","doi":"10.1158/1538-7445.am2023-5548","title":"Abstract 5548: Clinical management and decision making in early ER-positive breast cancers through improved prognosis and pathway directed molecular profiling","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"Medicine; Breast cancer; Oncology; Internal medicine; Precision medicine; Personalized medicine; Bioinformatics; Cancer; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001317574,0.0002845236,0.0004714084,0.0004303687,0.0001500364,0.0009468371,0.0002984953,0.0003256975,0.002262586],"category_scores_gemma":[0.002589739,0.0000951116,0.0003485983,0.0003669443,0.0001902854,0.0004355147,0.0003324765,0.0006818508,0.0006064452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000511606,"about_ca_system_score_gemma":0.0005997696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005960946,"about_ca_topic_score_gemma":0.001022876,"domain_scores_codex":[0.9995004,0.0002052289,0.00003552277,0.00008231392,0.0001326759,0.00004385979],"domain_scores_gemma":[0.9993638,0.00026514,0.0001452317,0.00004938662,0.0001045023,0.00007188494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.005988,0.001088577,0.2149334,0.0006233819,0.0005562841,0.0005178748,0.0002396805,0.01000705,0.06622496,0.001809497,0.01918908,0.6788223],"study_design_scores_gemma":[0.00177985,0.008048452,0.7026466,0.0009340544,0.001849361,0.003809614,0.0006753242,0.09279061,0.09107,0.02165176,0.07449146,0.0002529604],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9362089,0.01797771,0.02159737,0.00882977,0.000390036,0.0002956924,0.002466304,0.0004978119,0.01173635],"genre_scores_gemma":[0.9802644,0.002235595,0.01393608,0.001044234,0.0001535861,0.00008160755,0.001097378,0.00003240995,0.001154603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002262586,"threshold_uncertainty_score":0.007569134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04381208628055051,"score_gpt":0.3975511263349319,"score_spread":0.3537390400543814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}