{"id":"W4380051124","doi":"10.3390/biomedicines11061663","title":"Apabetalone Downregulates Fibrotic, Inflammatory and Calcific Processes in Renal Mesangial Cells and Patients with Renal Impairment","year":2023,"lang":"en","type":"article","venue":"Biomedicines","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Resverlogix (Canada)","funders":"","keywords":"Fibrosis; Inflammation; Periostin; Biology; Endocrinology; Myofibroblast; Internal medicine; Extracellular matrix; Cancer research; Medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001474825,0.0001684245,0.0003061872,0.0005111401,0.00005735562,0.00001849783,0.00002981186,0.00006600438,0.00004979892],"category_scores_gemma":[0.00003873926,0.0001099837,0.00002408354,0.0007729361,0.0002727066,0.00008201531,0.00003727536,0.00007837205,0.00001325824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002461713,"about_ca_system_score_gemma":0.00006696303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003240024,"about_ca_topic_score_gemma":0.00003836718,"domain_scores_codex":[0.99888,0.00002148542,0.0002659624,0.0002807966,0.0003133225,0.0002383751],"domain_scores_gemma":[0.9994715,0.00005409976,0.00006988185,0.0001199624,0.0001007008,0.0001838898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001292886,0.0006345331,0.7757549,0.00279624,0.0003445209,0.0005443779,0.002790856,0.00001447122,0.1971598,0.00001450698,0.01275329,0.005899643],"study_design_scores_gemma":[0.006630794,0.0009267405,0.9718544,0.002487926,0.0001473411,0.00002815995,0.0004581938,0.0001782839,0.01530729,0.00003079512,0.0016967,0.0002533923],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998317,0.0002113054,0.00000484987,0.000975127,0.00001820205,0.0002970258,0.00002460529,0.00007894397,0.00007293934],"genre_scores_gemma":[0.9989286,0.00009492696,0.00009271858,0.0001356713,0.0001313913,0.000023637,0.0001934765,0.00001581704,0.0003837318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1960995,"threshold_uncertainty_score":0.4485005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00592299520085742,"score_gpt":0.2204529573905973,"score_spread":0.2145299621897399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}