{"id":"W4380053056","doi":"10.1210/jcemcr/luad058","title":"Treatment of Homozygous Familial Hypercholesterolemia With ANGPTL3 Inhibitor, Evinacumab","year":2023,"lang":"en","type":"article","venue":"JCEM Case Reports","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; SickKids Foundation; Western University","funders":"Amryt Pharma; Ultragenyx Pharmaceutical; Canadian Institutes of Health Research; Esperion Therapeutics; Regeneron Pharmaceuticals; Academic Medical Organization of Southwestern Ontario; Sanofi; HLS Therapeutics; Amgen; Pfizer; Heart and Stroke Foundation of Canada","keywords":"Ezetimibe; Familial hypercholesterolemia; Medicine; LDL apheresis; PCSK9; Asymptomatic; Apheresis; Internal medicine; Adverse effect; Compound heterozygosity; Statin; LDL receptor; Gastroenterology; Cholesterol; Pediatrics; Lipoprotein; Mutation; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001048239,0.0002037693,0.0004857033,0.0001749326,0.00005787289,0.00001044118,0.00001552437,0.00009186802,0.00002800925],"category_scores_gemma":[0.00004931032,0.0001382826,0.0001348527,0.0003938674,0.00008568499,0.00007376573,0.0000229705,0.0000649502,0.00002496158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006605093,"about_ca_system_score_gemma":0.0002372913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005097432,"about_ca_topic_score_gemma":0.00006560793,"domain_scores_codex":[0.9985859,0.00002466046,0.0004164383,0.0003565201,0.0003327526,0.000283761],"domain_scores_gemma":[0.9988997,0.00003263999,0.0001623461,0.0006156313,0.0001001949,0.0001894914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0006358594,0.000953765,0.04234191,0.000265346,0.000227062,0.8899191,0.002145658,0.0000370924,0.008675182,0.00002850896,0.003443809,0.05132671],"study_design_scores_gemma":[0.009222119,0.004252826,0.0470001,0.0002418018,0.001235436,0.8049306,0.002580868,0.00009289691,0.0194119,0.00008669849,0.1103719,0.0005728705],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949817,0.0005115398,0.000006474954,0.0001609659,0.0004020456,0.0005159376,0.00001479029,0.0001676784,0.003238863],"genre_scores_gemma":[0.9970607,0.0002074983,0.0001396778,0.0000598661,0.0003370389,0.00005959116,0.00007189767,0.00003783986,0.002025918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1069281,"threshold_uncertainty_score":0.5639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01979929793660709,"score_gpt":0.2784904564975966,"score_spread":0.2586911585609895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}