{"id":"W4380075584","doi":"10.1016/j.heliyon.2023.e16651","title":"Integrative multiomics analysis of infant gut microbiome and serum metabolome reveals key molecular biomarkers of early onset childhood obesity","year":2023,"lang":"en","type":"article","venue":"Heliyon","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; Impact; Hamilton Health Sciences; McMaster University; Population Health Research Institute","funders":"Indian Council of Medical Research; Heart and Stroke Foundation of Canada; Canadian Foundation for Dietetic Research; Canadian Institutes of Health Research; Helderleigh Foundation; Genome Canada; Canada Foundation for Innovation; World Health Organization","keywords":"Metabolome; Overweight; Biology; Akkermansia; Body mass index; Microbiome; Childhood obesity; Obesity; Internal medicine; Physiology; Endocrinology; Medicine; Metabolomics; Bioinformatics; Genetics; Lactobacillus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004417552,0.0003972953,0.0004208873,0.0008823478,0.0002024691,0.0005504031,0.0001283529,0.0001888459,0.0007277562],"category_scores_gemma":[0.000582393,0.0001473827,0.0005368351,0.0008126229,0.000121768,0.0001997908,0.0004594158,0.0002780888,0.0001256563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002139483,"about_ca_system_score_gemma":0.0003886796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00540212,"about_ca_topic_score_gemma":0.008290661,"domain_scores_codex":[0.9998275,0.00004806438,0.00001127436,0.00004995798,0.00003330383,0.0000298868],"domain_scores_gemma":[0.9997775,0.0000435373,0.00007358213,0.0000274446,0.00003955672,0.00003845731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000977873,0.0001090056,0.8779232,0.00008491037,0.0005771036,0.0001974182,0.0002324243,0.0009889496,0.08509364,0.00009796255,0.0002324571,0.03348503],"study_design_scores_gemma":[0.000003444665,0.0001050109,0.9949697,0.000006860825,0.00009690029,0.000120466,0.0001212755,0.002300954,0.002020354,0.00006198549,0.0001880447,0.000005109011],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967368,0.0004558102,0.001751815,0.00003593142,0.000003108871,0.00001197121,0.000704088,0.00002290792,0.0002775875],"genre_scores_gemma":[0.9962267,0.0002479968,0.002293976,0.00002523086,0.000003952424,0.00001620066,0.0009184726,0.000010724,0.0002569359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00540212,"threshold_uncertainty_score":0.01074135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006570046434899606,"score_gpt":0.2557052397765708,"score_spread":0.2491351933416712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}