{"id":"W4380077901","doi":"10.1002/hon.3166_ot11","title":"A PHASE 1 STUDY EVALUATING PRT2527, A POTENT AND HIGHLY SELECTIVE CDK9 INHIBITOR, IN PATIENTS WITH SELECT RELAPSED/REFRACTORY B‐CELL MALIGNANCIES","year":2023,"lang":"en","type":"article","venue":"Hematological Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Gilead Sciences","keywords":"Lymphoma; Mantle cell lymphoma; Cancer research; Medicine; Aggressive lymphoma; Follicular lymphoma; B cell; Chronic lymphocytic leukemia; B-cell lymphoma; Internal medicine; Oncology; Rituximab; Immunology; Leukemia; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001040219,0.0002981604,0.0009605106,0.0003500878,0.0001255155,0.00001843486,0.0001289577,0.0003191685,0.00004263314],"category_scores_gemma":[0.001260437,0.0002013977,0.00005120839,0.001352135,0.0002637753,0.00008591671,0.0002457085,0.0006719599,0.0000908241],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005514096,"about_ca_system_score_gemma":0.004360698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001145321,"about_ca_topic_score_gemma":0.00007759539,"domain_scores_codex":[0.9964683,0.000584707,0.0005862308,0.0007734244,0.0007628137,0.0008245432],"domain_scores_gemma":[0.9978083,0.001066318,0.0001771364,0.0002961073,0.0003888395,0.0002632924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.03900301,0.07065506,0.8145734,0.001267271,0.0006286891,0.01956834,0.0133747,0.0001143783,0.008958112,0.0003058232,0.006957159,0.02459405],"study_design_scores_gemma":[0.4321904,0.283436,0.2621323,0.0004975146,0.0004265112,0.0009748749,0.004720191,0.009573971,0.003879971,0.0003734672,0.0008302617,0.0009645232],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957129,0.000159351,0.000009645383,0.000292885,0.00007161519,0.002581153,0.000004742224,0.0001727834,0.0009949631],"genre_scores_gemma":[0.9984281,0.00002744295,0.0005670477,0.0001960764,0.00004534275,0.0004094525,0.00003087444,0.00003578295,0.0002598579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5524411,"threshold_uncertainty_score":0.9983035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0422665373250659,"score_gpt":0.3692458672137403,"score_spread":0.3269793298886743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}