{"id":"W4380077901","doi":"10.1002/hon.3166_ot11","title":"A PHASE 1 STUDY EVALUATING PRT2527, A POTENT AND HIGHLY SELECTIVE CDK9 INHIBITOR, IN PATIENTS WITH SELECT RELAPSED/REFRACTORY B‐CELL MALIGNANCIES","year":2023,"lang":"en","type":"article","venue":"Hematological Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Gilead Sciences","keywords":"Lymphoma; Mantle cell lymphoma; Cancer research; Medicine; Aggressive lymphoma; Follicular lymphoma; B cell; Chronic lymphocytic leukemia; B-cell lymphoma; Internal medicine; Oncology; Rituximab; Immunology; Leukemia; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001041311,0.001669485,0.001305319,0.0005299882,0.0004642578,0.0008324225,0.00108009,0.0009736147,0.00369199],"category_scores_gemma":[0.0005258945,0.0005725807,0.001119104,0.0004032353,0.000774531,0.0006958194,0.0002942956,0.002148211,0.001077453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009831659,"about_ca_system_score_gemma":0.001768404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001799863,"about_ca_topic_score_gemma":0.004573185,"domain_scores_codex":[0.9997181,0.0000956615,0.00001143361,0.00007559246,0.00003273324,0.00006633771],"domain_scores_gemma":[0.9996253,0.0000436631,0.00005854152,0.00003265413,0.00002669746,0.000213158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4329543,0.1120745,0.0140581,0.001782261,0.002463297,0.001628146,0.0007808422,0.007466679,0.2199129,0.0009181085,0.01546703,0.1904939],"study_design_scores_gemma":[0.3531215,0.5998428,0.02048424,0.00006921789,0.0008111318,0.001447864,0.0001218434,0.001940005,0.01331305,0.0003812278,0.008412943,0.00005417195],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885015,0.002500455,0.0009937175,0.0004718688,0.00006319365,0.002991432,0.001573238,0.0001615841,0.002742898],"genre_scores_gemma":[0.9879004,0.001802564,0.001887821,0.0008142051,0.00007868254,0.002155331,0.002794018,0.00004342884,0.002523663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00369199,"threshold_uncertainty_score":0.01235098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0422665373250659,"score_gpt":0.3692458672137403,"score_spread":0.3269793298886743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}