{"id":"W4380078977","doi":"10.1002/hon.3164_442","title":"First interim analysis of a phase 1 study of zanubrutinib (zanu) + lenalidomide (len) in patients with relapsed/refractory (R/R) diffuse large B‐cell lymphoma (DLBCL)","year":2023,"lang":"en","type":"article","venue":"Hematological Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"AbbVie Canada; BeiGene; Regeneron Pharmaceuticals","keywords":"Medicine; Lenalidomide; Internal medicine; Refractory (planetary science); Interim analysis; Diffuse large B-cell lymphoma; Oncology; Lymphoma; Gastroenterology; Clinical trial; Multiple myeloma","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008096568,0.0003120841,0.002230994,0.001169088,0.00005589861,0.000005828007,0.0003536483,0.0003853268,0.0003433877],"category_scores_gemma":[0.0008610152,0.0002150432,0.0002605827,0.002924289,0.0003473901,0.0000696188,0.0004036331,0.0003211864,0.00005404677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003026281,"about_ca_system_score_gemma":0.001498906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003468751,"about_ca_topic_score_gemma":0.0006450253,"domain_scores_codex":[0.9960942,0.0004251165,0.00127775,0.0006783383,0.00077525,0.000749335],"domain_scores_gemma":[0.9965767,0.001591461,0.0005175645,0.0007770901,0.0002778347,0.0002593256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.03080152,0.3175178,0.633222,0.0008362054,0.002664149,0.004878072,0.006650853,0.00007357283,0.0003367969,0.0002488775,0.001077255,0.001692861],"study_design_scores_gemma":[0.6604878,0.03801407,0.2828973,0.0002487938,0.001763171,0.00005915961,0.004646663,0.009063674,0.0008062734,0.00004014535,0.001549116,0.0004238219],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975187,0.00008380106,0.00003026107,0.00009602762,0.00007188619,0.001256001,0.00004077163,0.00007617032,0.0008264449],"genre_scores_gemma":[0.9992849,0.00006002001,0.0001103802,0.00009832278,0.00001529659,0.0001355501,0.0001160599,0.00003133989,0.0001480876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6296863,"threshold_uncertainty_score":0.8769206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03837858987535493,"score_gpt":0.3586103973826119,"score_spread":0.3202318075072569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}