{"id":"W4380081039","doi":"10.3389/fimmu.2023.1150754","title":"PD-1 blockade attenuates surgery-mediated immunosuppression and boosts Th1 immunity perioperatively in oesophagogastric junctional adenocarcinoma","year":2023,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Cancer, Stress, Anesthesia, and Immune Response","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"","keywords":"Nivolumab; Ipilimumab; Medicine; Immune checkpoint; Cytotoxic T cell; Immune system; Immunity; Immunology; Durvalumab; Granzyme B; Cancer research; Peripheral blood mononuclear cell; T cell; Immunotherapy; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006190882,0.0003556464,0.0009342692,0.001633148,0.0001924795,0.00003138672,0.0001993074,0.000376719,0.0001201303],"category_scores_gemma":[0.0006989341,0.0003365319,0.0001389962,0.001310357,0.000565818,0.0002012473,0.0001710165,0.0008075453,0.00006162595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003363136,"about_ca_system_score_gemma":0.0004747249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007450513,"about_ca_topic_score_gemma":0.00004355357,"domain_scores_codex":[0.9973136,0.0005322599,0.0006694288,0.0005125695,0.00024285,0.0007293448],"domain_scores_gemma":[0.998683,0.00053503,0.0001508211,0.0004522025,0.00009208268,0.0000868999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0053818,0.0002489907,0.951827,0.00007817344,0.0001907622,0.000497644,0.001868967,0.00001631138,0.01846782,0.000009702087,0.009567463,0.0118453],"study_design_scores_gemma":[0.003429746,0.0002973505,0.9815792,0.0002569417,0.00003645805,0.0003816614,0.003332968,0.0005229476,0.002101721,0.0000491044,0.007738156,0.0002737812],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9534432,0.04285317,0.0000160742,0.001538185,0.001471584,0.0004491809,0.00002378577,0.0001172302,0.00008761638],"genre_scores_gemma":[0.9861251,0.01139862,0.000236548,0.0001450894,0.000143911,0.0001442916,0.0003311985,0.00005359323,0.001421647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03268192,"threshold_uncertainty_score":0.9999087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01429290617913235,"score_gpt":0.2429980678890589,"score_spread":0.2287051617099266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}