{"id":"W4380081914","doi":"10.21203/rs.3.rs-2841179/v1","title":"Adaptive evaluation of mHealth and conventional adherence support interventions to optimize outcomes with new treatment regimens for drug-resistant tuberculosis and HIV in South Africa (ADAP-TIV): Study protocol for an adaptive randomized controlled trial","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"HIV/AIDS Research and Interventions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Columbia College","funders":"National Institutes of Health","keywords":"mHealth; Tuberculosis; Psychological intervention; Protocol (science); Human immunodeficiency virus (HIV); Medicine; Medication adherence; Drug; Computer science; Intensive care medicine; Pharmacology; Virology; Alternative medicine; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02205111,0.006772721,0.007971639,0.001817239,0.002370211,0.002914401,0.002724708,0.006228357,0.05146974],"category_scores_gemma":[0.02092956,0.003191075,0.004335812,0.001732357,0.004736664,0.003267041,0.002500777,0.006066828,0.006077871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003302011,"about_ca_system_score_gemma":0.007778126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00318442,"about_ca_topic_score_gemma":0.002984857,"domain_scores_codex":[0.9867339,0.006878625,0.001545293,0.001685889,0.001281322,0.001874917],"domain_scores_gemma":[0.9932268,0.002855266,0.001308664,0.0008781665,0.0008886459,0.0008424274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9701046,0.0104963,0.00028299,0.001933637,0.0007485991,0.00002524623,0.0001180296,0.0007035416,0.0005112627,0.0007099185,0.00119905,0.01316686],"study_design_scores_gemma":[0.9795105,0.01719952,0.0004327588,0.0001526322,0.0002897762,0.000005288153,0.00001939357,0.0003817317,0.0002342456,0.0003898962,0.001364549,0.00001975421],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.05455095,0.0006535693,0.004128995,0.0003691084,0.0007544874,0.9332092,0.002794896,0.0003322302,0.003206562],"genre_scores_gemma":[0.03130184,0.0002576516,0.006512041,0.0002047532,0.0001503508,0.959789,0.0003033245,0.0000225573,0.001458368],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.05146974,"threshold_uncertainty_score":0.1721835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3269989892679094,"score_gpt":0.5293081655410585,"score_spread":0.2023091762731491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}