{"id":"W4380083458","doi":"10.1002/hon.3164_446","title":"Glofitamab plus immunochemotherapy demonstrates durable efficacy with manageable safety in relapsed/refractory non‐Hodgkin lymphoma (R/R NHL): update of a Phase Ib study","year":2023,"lang":"en","type":"article","venue":"Hematological Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"F. Hoffmann-La Roche","keywords":"Medicine; Tolerability; Obinutuzumab; Internal medicine; Rituximab; CHOP; Refractory (planetary science); Gastroenterology; Lymphoma; CD20; Oncology; Dosing; Phases of clinical research; Immunology; Adverse effect; Chemotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001404587,0.0004095813,0.001823742,0.000522823,0.0001202298,0.00001910124,0.0004165766,0.0004636248,0.002622466],"category_scores_gemma":[0.0002303405,0.0002956919,0.000186242,0.001800478,0.0005471582,0.00008167589,0.0001790393,0.000603116,0.0002756674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006024977,"about_ca_system_score_gemma":0.0006969441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002197074,"about_ca_topic_score_gemma":0.0001446271,"domain_scores_codex":[0.9960961,0.0005173232,0.001031598,0.0007885232,0.0005850125,0.0009813989],"domain_scores_gemma":[0.9973021,0.001203455,0.0002818115,0.0007945923,0.0001658478,0.0002521615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2009479,0.07920053,0.1153731,0.001215884,0.003092713,0.0526033,0.006562002,0.0005945668,0.2774408,0.002187407,0.005573884,0.2552078],"study_design_scores_gemma":[0.44749,0.09664349,0.3130981,0.000968778,0.0006353893,0.005440102,0.01861276,0.009201545,0.05021518,0.00115646,0.0544313,0.002106864],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856672,0.0003692139,0.00006975226,0.001519574,0.00009187419,0.002492061,0.00001031822,0.0002100204,0.009569975],"genre_scores_gemma":[0.9955402,0.0007317093,0.0008364262,0.0003156836,0.00004052937,0.0002244061,0.00005439509,0.00006452201,0.002192141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.253101,"threshold_uncertainty_score":0.9999495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03626881542327003,"score_gpt":0.3635415401709561,"score_spread":0.327272724747686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}