{"id":"W4380084397","doi":"10.3390/ijms24129902","title":"Chitosomes Loaded with Docetaxel as a Promising Drug Delivery System to Laryngeal Cancer Cells: An In Vitro Cytotoxic Study","year":2023,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"National Institute on Deafness and Other Communication Disorders; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Docetaxel; Nanocarriers; Pharmacology; Liposome; Drug delivery; Cytotoxicity; Chemotherapy; Cancer cell; Bioavailability; In vitro; Medicine; Chemistry; Cancer; Drug; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000572891,0.0001403138,0.0001745282,0.0004016851,0.00006158167,0.0001430155,0.000836723,0.00003858392,0.000004960985],"category_scores_gemma":[0.00002397243,0.0001086741,0.00007244539,0.0003434248,0.00006955321,0.00004020186,0.0001305177,0.0001056027,0.00001028141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005335055,"about_ca_system_score_gemma":0.0003421447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002488675,"about_ca_topic_score_gemma":0.0001793488,"domain_scores_codex":[0.9983144,0.0001089879,0.0003307265,0.0003113658,0.0006956252,0.0002388791],"domain_scores_gemma":[0.9992684,0.00001147323,0.0001864257,0.0001204435,0.0002942552,0.0001190598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004209416,0.0001222264,0.002175962,0.000004931274,0.00009818601,0.0005090403,0.0005630778,0.005847336,0.9885167,0.000004578303,0.00005569935,0.001681352],"study_design_scores_gemma":[0.0007147482,0.001091803,0.002374212,0.0001260237,0.00001613082,0.0001216383,0.004663982,0.0003700971,0.9902872,0.00001316832,0.00006280479,0.0001581719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985737,0.0002389793,0.0001199398,0.0003027529,0.0004441134,0.0001898218,0.000009688364,0.000008789742,0.0001122758],"genre_scores_gemma":[0.9990891,0.00004546774,0.0003623399,0.0002381278,0.0001921823,0.00001682218,0.00000431178,0.00001127387,0.00004040174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005477239,"threshold_uncertainty_score":0.4431603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01343735718805686,"score_gpt":0.293630867399025,"score_spread":0.2801935102109681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}