{"id":"W4380084604","doi":"10.1038/s41598-023-36609-z","title":"Exogenously delivered iPSCs disrupt the natural repair response of endogenous MPCs after bone injury","year":2023,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Alberta Bone and Joint Health Institute; University of Calgary","funders":"Cumming School of Medicine, University of Calgary; Canadian Institutes of Health Research; Alberta Innovates; Natural Sciences and Engineering Research Council of Canada; Osteoporosis Canada","keywords":"Induced pluripotent stem cell; Endogeny; Bone healing; Mesenchymal stem cell; Stem cell; Progenitor cell; Medicine; Cell biology; Biology; Pathology; Surgery; Internal medicine; Embryonic stem cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001724207,0.0002793947,0.0002816606,0.0003031005,0.0001001919,0.0003275925,0.0002561234,0.0003858632,0.001451246],"category_scores_gemma":[0.0001314176,0.0001909928,0.0003206243,0.0001191892,0.0002694167,0.0001674265,0.000233017,0.0009566356,0.0004672262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001273956,"about_ca_system_score_gemma":0.0002113231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002800726,"about_ca_topic_score_gemma":0.0004092644,"domain_scores_codex":[0.9997249,0.00001728403,0.00003959899,0.00004444683,0.0001254317,0.00004838614],"domain_scores_gemma":[0.9998492,0.00002560874,0.000052635,0.00002382213,0.00001708978,0.00003163027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005228501,0.00003360142,0.0001845297,0.0000440352,0.000005131577,0.00007879442,0.00002328319,0.0001062254,0.9976845,0.0001536493,0.00003274544,0.001601196],"study_design_scores_gemma":[0.00001217417,0.0002540054,0.003583848,0.00001871348,0.00002787843,0.0002418115,0.00005640154,0.0008754241,0.9918153,0.00008162261,0.0030291,0.000003751079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883174,0.001484359,0.007007908,0.00009268086,0.00007401815,0.00006550924,0.0005212501,0.0001757571,0.00226117],"genre_scores_gemma":[0.9889457,0.001187975,0.003772686,0.00009310044,0.0000171563,0.0001096136,0.0007530625,0.00005199789,0.005068708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001451246,"threshold_uncertainty_score":0.004854918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03479146378383659,"score_gpt":0.3028810059269237,"score_spread":0.2680895421430871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}