{"id":"W4380085777","doi":"10.20944/preprints202306.0605.v1","title":"Synthesis and Evaluation of 99mTc-labeled PSMA-targeted Tracers Based on the Lys-urea-Aad Pharmacophore for Detecting Prostate Cancer with Single Photon Emission Computed Tomography","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Terry Fox Research Institute","funders":"","keywords":"LNCaP; Prostate cancer; Chemistry; Biodistribution; Pharmacophore; Urea; In vivo; Glutamate carboxypeptidase II; Positron emission tomography; Imaging agent; In vitro; Cancer; Cancer research; Nuclear medicine; Biochemistry; Medicine; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003863158,0.0003804271,0.00040444,0.0002787372,0.0001672797,0.0002915382,0.0003687666,0.000574454,0.0003953682],"category_scores_gemma":[0.0003993518,0.0002362707,0.0002516794,0.000339164,0.0002517951,0.0004155292,0.0002598438,0.0004596048,0.0002409903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006334208,"about_ca_system_score_gemma":0.0004703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001078213,"about_ca_topic_score_gemma":0.001377409,"domain_scores_codex":[0.9998512,0.00003284596,0.00001168513,0.0000297091,0.00005115367,0.00002338524],"domain_scores_gemma":[0.9997919,0.0000308613,0.00005394506,0.00001672516,0.00004951839,0.00005700647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008784451,0.00003779925,0.0001037661,0.00007575342,0.000006776148,0.00005464975,0.00002717662,0.0004575593,0.9965762,0.0001403358,0.00002923026,0.002402896],"study_design_scores_gemma":[0.0000301021,0.000750864,0.0005190739,0.000006224942,0.00002173759,0.0001804855,0.00001429496,0.003180782,0.9935017,0.00002170453,0.001756809,0.00001614501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775037,0.00264446,0.01821743,0.00008780403,0.0000257722,0.0002788108,0.0001995416,0.0001091233,0.0009335203],"genre_scores_gemma":[0.9523154,0.002139515,0.04284422,0.00008985985,0.00001532673,0.0002378277,0.000415484,0.00003920935,0.001903271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001078213,"threshold_uncertainty_score":0.004595816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1977814292780957,"score_gpt":0.4094482225892699,"score_spread":0.2116667933111743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}