{"id":"W4380148730","doi":"10.1101/2023.06.08.544248","title":"De novo design of a <i>β</i> -helix tau protein scaffold: An oligomer-selective vaccine immunogen candidate for Alzheimer’s disease","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Genome British Columbia; University of British Columbia","funders":"Canadian Institutes of Health Research; Alberta Innovates; Compute Canada","keywords":"Epitope; Immunogen; Oligomer; Helix (gastropod); Chemistry; Tau protein; Epitope mapping; Linker; Linear epitope; Biophysics; Computational biology; Monoclonal antibody; Biology; Computer science; Antibody; Alzheimer's disease; Genetics; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002059194,0.000341082,0.0002492216,0.0002224058,0.000133168,0.0002946687,0.0002671838,0.0002067952,0.0005251699],"category_scores_gemma":[0.0001842431,0.000157127,0.0002922885,0.0001383716,0.0001226408,0.0001658328,0.0002219643,0.0002834417,0.0002754799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002938291,"about_ca_system_score_gemma":0.0003119433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002868254,"about_ca_topic_score_gemma":0.0004924093,"domain_scores_codex":[0.999934,0.00001154976,0.000004106023,0.00001594832,0.00001968314,0.00001479265],"domain_scores_gemma":[0.999915,0.000008668007,0.00002788371,0.000006905981,0.00001864837,0.00002290063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001406943,0.0001712028,0.000753817,0.00008154674,0.00002085679,0.0001532102,0.00003389914,0.04535656,0.943233,0.001028042,0.0001409821,0.008886338],"study_design_scores_gemma":[0.00007426908,0.002455807,0.00130647,0.00001441058,0.00006529847,0.0001778899,0.0000715773,0.2442288,0.7464486,0.000551444,0.004581023,0.00002427157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9502876,0.0002878931,0.04740073,0.00005556898,0.00001984718,0.0001099447,0.0001034556,0.000111045,0.001623926],"genre_scores_gemma":[0.9547605,0.0002426135,0.04378829,0.00002664093,0.00000467866,0.00007506474,0.0001814248,0.00002001714,0.0009007124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005251699,"threshold_uncertainty_score":0.002131939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01543930112778349,"score_gpt":0.2455918555058474,"score_spread":0.2301525543780639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}