{"id":"W4380149798","doi":"10.1016/j.jval.2023.03.1433","title":"HTA4 Pembrolizumab Vs. Standard of Care Chemotherapy As First-Line Treatment for Advanced Non-Small Cell Lung Cancer with High Pd-L1 Expression Levels: A Cost-Utility Analysis from the Ontario, Canada Public Payer Perspective","year":2023,"lang":"en","type":"article","venue":"Value in Health","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Sunnybrook Health Science Centre; York University; University of Toronto","funders":"","keywords":"Pembrolizumab; Medicine; Lung cancer; Chemotherapy; Oncology; Internal medicine; Cancer; Intensive care medicine; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00236705,0.0007028366,0.001586705,0.0007194527,0.0004339576,0.001990373,0.00119413,0.0009965284,0.004750427],"category_scores_gemma":[0.005620612,0.0004458034,0.003575407,0.001523537,0.0006001341,0.000708145,0.0005087798,0.001524612,0.0001894999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.03113281,"about_ca_system_score_gemma":0.01580244,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.6116062,"about_ca_topic_score_gemma":0.6810049,"domain_scores_codex":[0.9982514,0.000812343,0.00007119784,0.000140274,0.0003322212,0.0003925565],"domain_scores_gemma":[0.998069,0.0009424802,0.0003703488,0.00005693879,0.0002026104,0.0003586076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.3668616,0.001956495,0.1307041,0.005565561,0.0289562,0.001182262,0.0005260678,0.1636522,0.00390834,0.01374944,0.02956293,0.2533747],"study_design_scores_gemma":[0.06094764,0.02548034,0.5517007,0.002871812,0.05435889,0.001602983,0.001866393,0.252244,0.002426845,0.009662289,0.03639195,0.0004462028],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9335945,0.03101289,0.001249646,0.005220972,0.0002430627,0.0006276126,0.01002434,0.0000694314,0.01795743],"genre_scores_gemma":[0.9945018,0.002410252,0.0004083687,0.000379164,0.00003936015,0.00004488798,0.001080048,0.000008711931,0.001127313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3883938,"threshold_uncertainty_score":0.7813622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0349656346771366,"score_gpt":0.3159447320730994,"score_spread":0.2809790973959628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}