{"id":"W4380150929","doi":"10.1016/j.jep.2023.116770","title":"The antihyperuricemia activity of Astragali Radix through regulating the expression of uric acid transporters via PI3K/Akt signalling pathway","year":2023,"lang":"en","type":"article","venue":"Journal of Ethnopharmacology","topic":"Gout, Hyperuricemia, Uric Acid","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ministry of Agriculture","funders":"Major Scientific and Technological Innovation Project of Shandong Province; Natural Science Foundation of Shandong Province; Texas Space Grant Consortium","keywords":"Hyperuricemia; Uric acid; Xanthine oxidase; Astragalus; Pharmacology; Chemistry; Creatinine; Xanthine; Mechanism of action; Blood urea nitrogen; Biochemistry; Traditional medicine; Medicine; Traditional Chinese medicine; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002494827,0.0002828054,0.0008540435,0.0002088183,0.0003067807,0.000009990008,0.0005396153,0.0002635095,0.0001149743],"category_scores_gemma":[0.0002844285,0.0001605828,0.0004479782,0.0009291993,0.0004746284,0.0002462371,0.00007973849,0.001451658,0.000005510889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001000747,"about_ca_system_score_gemma":0.0003495108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000213907,"about_ca_topic_score_gemma":0.000001568765,"domain_scores_codex":[0.9965932,0.0005322176,0.001266333,0.0002490729,0.0008403446,0.0005187849],"domain_scores_gemma":[0.9962667,0.001441399,0.001419024,0.0003361794,0.0003910688,0.0001455864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001216359,0.000180967,0.0009979873,0.0001651094,0.0003983862,0.0002479919,0.003298925,0.00119969,0.9825861,0.00001019488,0.001002849,0.008695451],"study_design_scores_gemma":[0.002875113,0.0006837709,0.007458162,0.0002636433,0.0006653756,0.0002679279,0.001206498,0.0007691847,0.9844585,0.000146613,0.001064264,0.0001409562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921617,0.001628177,0.001870577,0.002645545,0.001049889,0.0003888163,0.000009476506,0.00003321813,0.0002125898],"genre_scores_gemma":[0.9975466,0.000767694,0.0008419646,0.0002003669,0.0004874076,0.000008723694,0.00000283522,0.00004634101,0.00009809113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008554494,"threshold_uncertainty_score":0.6548378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03423270158716363,"score_gpt":0.3211464683343324,"score_spread":0.2869137667471688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}