{"id":"W4380151393","doi":"10.1016/j.jval.2023.03.119","title":"CO45 Durability of Efficacy and Safety of Roflumilast Cream 0.3% in Adults with Chronic Plaque Psoriasis from a 52-Week, Phase 2 Open-Label Safety Trial","year":2023,"lang":"en","type":"article","venue":"Value in Health","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Probity Medical Research; University of British Columbia; Queen's University","funders":"","keywords":"Roflumilast; Open label; Medicine; Psoriasis; Dermatology Life Quality Index; Plaque psoriasis; Safety profile; Adverse effect; Psoriasis Area and Severity Index; Body surface area; Dermatology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002228781,0.0001844125,0.0009856359,0.0001132129,0.0000821811,0.000008215595,0.0001556536,0.00009639318,0.00008390634],"category_scores_gemma":[0.001054375,0.0001442226,0.0000314489,0.0007620078,0.0001904189,0.0001298917,0.0001751732,0.0004297646,0.000004183835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003111506,"about_ca_system_score_gemma":0.0007013559,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0353024,"about_ca_topic_score_gemma":0.002309118,"domain_scores_codex":[0.997176,0.0005575224,0.00109118,0.0004465152,0.0003251589,0.0004036269],"domain_scores_gemma":[0.996327,0.002676873,0.0003826735,0.0003176938,0.00006643371,0.0002293325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8775389,0.01606734,0.01757267,0.00356912,0.0002789324,0.00007056203,0.00493817,0.0004716055,0.0003046825,0.0003034953,0.0004306651,0.07845385],"study_design_scores_gemma":[0.7539229,0.03095129,0.1856303,0.005025482,0.0001524167,0.00001021507,0.001103563,0.01132786,0.0006031863,0.0002206435,0.01070911,0.000343023],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873383,0.002086248,0.00001137214,0.006903992,0.0001673066,0.002864915,0.0002913385,0.00002270624,0.0003137913],"genre_scores_gemma":[0.9874866,0.01178063,0.0002838481,0.0001753709,0.0001328638,0.00005038173,0.00005899733,0.00001834483,0.00001298743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1680577,"threshold_uncertainty_score":0.9711216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.136141081805109,"score_gpt":0.428183312101855,"score_spread":0.292042230296746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}