{"id":"W4380151393","doi":"10.1016/j.jval.2023.03.119","title":"CO45 Durability of Efficacy and Safety of Roflumilast Cream 0.3% in Adults with Chronic Plaque Psoriasis from a 52-Week, Phase 2 Open-Label Safety Trial","year":2023,"lang":"en","type":"article","venue":"Value in Health","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Probity Medical Research; University of British Columbia; Queen's University","funders":"","keywords":"Roflumilast; Open label; Medicine; Psoriasis; Dermatology Life Quality Index; Plaque psoriasis; Safety profile; Adverse effect; Psoriasis Area and Severity Index; Body surface area; Dermatology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002306638,0.00071918,0.001628206,0.0003001035,0.0003806538,0.000897021,0.0003869016,0.001245054,0.005025413],"category_scores_gemma":[0.00208063,0.0003418185,0.001405776,0.0002471007,0.0006075783,0.0008890018,0.0003060131,0.002142434,0.001396775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004409105,"about_ca_system_score_gemma":0.0006184917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004872971,"about_ca_topic_score_gemma":0.0009780593,"domain_scores_codex":[0.9989417,0.000460052,0.0001030773,0.0001728734,0.0001540041,0.0001682628],"domain_scores_gemma":[0.9986539,0.0004271855,0.0003265656,0.0001343392,0.0001467896,0.000311176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8285782,0.01080129,0.004667326,0.001081566,0.00206477,0.0001281021,0.0001697682,0.0004890669,0.02493837,0.0001778729,0.003196995,0.1237066],"study_design_scores_gemma":[0.6291907,0.323165,0.03389145,0.0001166668,0.001823203,0.0002760064,0.00007498778,0.0007560716,0.005482706,0.0002207021,0.004942882,0.00005953274],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813319,0.008642014,0.0007075291,0.0007915446,0.0002617484,0.001775182,0.002139473,0.0001116794,0.004238955],"genre_scores_gemma":[0.991381,0.002008039,0.0006965075,0.0008253069,0.0003497387,0.0008013083,0.00157665,0.00002325266,0.002338232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005025413,"threshold_uncertainty_score":0.01681167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.136141081805109,"score_gpt":0.428183312101855,"score_spread":0.292042230296746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}