{"id":"W4380202384","doi":"10.1016/j.ijbiomac.2023.125332","title":"pH-sensitive HPMCP-chitosan nanoparticles containing 5-aminosalicylic acid and berberine for oral colon delivery in a rat model of ulcerative colitis","year":2023,"lang":"en","type":"article","venue":"International Journal of Biological Macromolecules","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Laurentian University","funders":"Shahroud University of Medical Sciences","keywords":"Ulcerative colitis; Aminosalicylic acid; Berberine; Drug delivery; Pharmacology; Bioavailability; Drug; In vivo; Chitosan; Chemistry; Medicine; Gastroenterology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001339116,0.0003559327,0.0003363922,0.0001955656,0.0001341716,0.0001256932,0.0001823676,0.0003904777,0.0007430398],"category_scores_gemma":[0.00009183813,0.0001714463,0.0002695706,0.0001084847,0.0001804391,0.0002596541,0.0001024022,0.0004912857,0.0001344189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000225307,"about_ca_system_score_gemma":0.000252506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001607744,"about_ca_topic_score_gemma":0.002701366,"domain_scores_codex":[0.9999096,0.000009722767,0.000006161259,0.00002172179,0.00002305914,0.00002975589],"domain_scores_gemma":[0.999943,0.000007773105,0.00001966294,0.000004896212,0.00001057135,0.00001408545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004250733,0.00006730364,0.00002191572,0.00006727951,0.000005157655,0.00002772212,0.00000952856,0.00008871948,0.9975382,0.00002843458,0.00002758377,0.001693084],"study_design_scores_gemma":[0.00004406169,0.001449389,0.0008684146,0.000005300086,0.00003870055,0.00007902022,0.00001011522,0.0005938375,0.996103,0.00001137877,0.0007902349,0.000006588407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934052,0.002332255,0.002899788,0.0001010357,0.00009838992,0.00006614765,0.0001017928,0.00008077527,0.0009146066],"genre_scores_gemma":[0.9916682,0.001501776,0.003792123,0.00004499556,0.00002103549,0.0000523044,0.00007856884,0.00001511247,0.002825715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001607744,"threshold_uncertainty_score":0.003196716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0633078750765895,"score_gpt":0.351598452811794,"score_spread":0.2882905777352045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}