{"id":"W4380234055","doi":"10.1016/j.jtct.2023.06.007","title":"Leukapheresis and Tisagenlecleucel Manufacturing Outcomes in Patients Age &lt;3 Years with Relapsed/Refractory Acute Lymphoblastic Leukemia","year":2023,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Novartis (Canada)","funders":"Novartis Pharmaceuticals Corporation","keywords":"Leukapheresis; Medicine; Blinatumomab; Leukemia; Lymphoblastic Leukemia; Immunology; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001313635,0.0001463094,0.0002665445,0.0006210509,0.0002622933,0.0007971954,0.0002011271,0.0003261661,0.001316732],"category_scores_gemma":[0.003165131,0.0001029129,0.0005107869,0.001078366,0.0002334777,0.0005443962,0.0004248518,0.0006313921,0.0003295694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007119271,"about_ca_system_score_gemma":0.0003921694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001991885,"about_ca_topic_score_gemma":0.002095997,"domain_scores_codex":[0.9992805,0.0001510401,0.000115641,0.0001334297,0.0002027906,0.0001165895],"domain_scores_gemma":[0.9963273,0.0005554105,0.002499452,0.0001316557,0.0002310004,0.0002550901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002690002,0.0001136715,0.9856042,0.00003172148,0.00008655161,0.0002432786,0.0001720848,0.0002621263,0.001154471,0.00008482237,0.0004918308,0.009065291],"study_design_scores_gemma":[0.00006746095,0.00132664,0.9947101,0.00001546206,0.00008102976,0.0008360241,0.0001734522,0.0004150694,0.0009495612,0.00006245077,0.001354289,0.000008418625],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99822,0.0005157842,0.00008449343,0.0000533056,0.000004203002,0.00001260177,0.0005675448,0.000006015611,0.0005360331],"genre_scores_gemma":[0.9984012,0.000147063,0.0000880481,0.00007396335,0.000008712092,0.00001025257,0.001136808,0.000004471592,0.0001294494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001991885,"threshold_uncertainty_score":0.006947279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01585269188541878,"score_gpt":0.2538842574436235,"score_spread":0.2380315655582048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}