{"id":"W4380271199","doi":"10.1101/2023.06.08.544220","title":"Differences in the transcriptome response in the gills of sea lamprey acutely exposed to 3-trifluoromethyl-4-nitrophenol (TFM), niclosamide or a TFM:niclosamide mixture","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Fish Ecology and Management Studies","field":"Environmental Science","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; University of Regina; University of Manitoba","funders":"Fisheries and Oceans Canada; U.S. Geological Survey; Great Lakes Fishery Commission","keywords":"Niclosamide; Lamprey; Transcriptome; Biology; Zebrafish; Gill; Petromyzon; Gene; Gene expression; Pharmacology; Biochemistry; Fishery; Ecology; Fish <Actinopterygii>","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005208576,0.0002830089,0.0003237546,0.0001677143,0.0002003893,0.000221967,0.0001016972,0.0002492532,0.001194087],"category_scores_gemma":[0.00006473761,0.0001501942,0.000321926,0.0001362863,0.0001691269,0.0001485967,0.000206728,0.0003064025,0.0002074647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002616404,"about_ca_system_score_gemma":0.0001931502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002107287,"about_ca_topic_score_gemma":0.004343887,"domain_scores_codex":[0.999934,0.000005803856,0.000003930274,0.00002481059,0.00001518472,0.00001632786],"domain_scores_gemma":[0.9999579,0.000003791759,0.00001083193,0.000002387661,0.00001415401,0.00001081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009368727,0.000005927664,0.0006241076,0.00003428185,0.000005912128,0.00002061897,0.00002385416,0.00001427443,0.9988171,0.000007398826,0.00002085436,0.0003319976],"study_design_scores_gemma":[0.00002043879,0.001101838,0.3975982,0.00003595708,0.0001323166,0.0002678069,0.0008782196,0.001040839,0.5945886,0.00007142292,0.004233175,0.00003117571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962852,0.0007663492,0.0005770032,0.00006809226,0.00002169678,0.00002306782,0.001434434,0.00002710352,0.0007970933],"genre_scores_gemma":[0.9878635,0.0007604164,0.001596873,0.0002090503,0.00001195077,0.0001237839,0.002577299,0.000021281,0.006835862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002107287,"threshold_uncertainty_score":0.004189968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03024738600570188,"score_gpt":0.2353583717981818,"score_spread":0.2051109857924799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}