{"id":"W4380302352","doi":"10.1093/neuonc/noad073.245","title":"MDB-12. TRANS-SPECIES ANALYSIS OF REPLICATION-REPAIR DEFICIENT (RRD) MEDULLOBLASTOMA AND RESPONSE TO IMMUNE-CHECKPOINT INHIBITION: AN IRRDC REPORT","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Hospital for Sick Children","funders":"","keywords":"Medulloblastoma; Cancer research; Biology; Sonic hedgehog; Transcriptome; Microsatellite instability; Immune checkpoint; Chromosome instability; Immune system; Immunotherapy; Genetics; Gene; Gene expression; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001573552,0.0002225221,0.0007928376,0.0009374277,0.00009801892,0.00001088042,0.0001241274,0.0002155336,0.0002935897],"category_scores_gemma":[0.001875939,0.0002149508,0.0002917367,0.001987731,0.0002659162,0.00004593312,0.0001230801,0.0002445311,0.00002060127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003563432,"about_ca_system_score_gemma":0.0004828849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005876295,"about_ca_topic_score_gemma":0.0003111039,"domain_scores_codex":[0.9969316,0.0003668635,0.0009637513,0.0009048333,0.0004752113,0.0003577228],"domain_scores_gemma":[0.9970931,0.0007173264,0.0002779028,0.001305088,0.0003156819,0.0002909011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003406568,0.0002250581,0.01056882,0.00003970155,0.0002437031,0.0006523514,0.002781488,0.0003512714,0.9786779,0.00003370197,0.001184037,0.001835408],"study_design_scores_gemma":[0.001337462,0.006596506,0.6744475,0.0000327124,0.001102585,0.0008744559,0.001127112,0.0008785255,0.2205447,0.00005062075,0.0927552,0.0002526438],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897713,0.00009296867,0.0001115667,0.007012381,0.0003489429,0.0007170162,0.00004150451,0.000269265,0.001635033],"genre_scores_gemma":[0.9971804,0.00007715695,0.001147868,0.0007204263,0.0000673798,0.0002000897,0.00008725435,0.0000369521,0.0004824739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7581332,"threshold_uncertainty_score":0.876544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03871376592034477,"score_gpt":0.3327544107041853,"score_spread":0.2940406447838406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}