{"id":"W4380302352","doi":"10.1093/neuonc/noad073.245","title":"MDB-12. TRANS-SPECIES ANALYSIS OF REPLICATION-REPAIR DEFICIENT (RRD) MEDULLOBLASTOMA AND RESPONSE TO IMMUNE-CHECKPOINT INHIBITION: AN IRRDC REPORT","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Hospital for Sick Children","funders":"","keywords":"Medulloblastoma; Cancer research; Biology; Sonic hedgehog; Transcriptome; Microsatellite instability; Immune checkpoint; Chromosome instability; Immune system; Immunotherapy; Genetics; Gene; Gene expression; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001893192,0.0002225549,0.0002995038,0.0005783588,0.0001783796,0.0002704395,0.0001629875,0.000240933,0.001644842],"category_scores_gemma":[0.0001505193,0.0001160023,0.0002862274,0.0002803179,0.0002118062,0.00008719514,0.0002538704,0.0002733771,0.0004114959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002834628,"about_ca_system_score_gemma":0.0001392332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008061819,"about_ca_topic_score_gemma":0.0008691823,"domain_scores_codex":[0.9998685,0.00001532555,0.00001157011,0.00004623007,0.00002942819,0.00002892308],"domain_scores_gemma":[0.9998193,0.00001974782,0.0000562944,0.00002825557,0.00001907057,0.00005732801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009326753,0.00007217504,0.02694754,0.00006447438,0.00003158219,0.0003601906,0.0000473335,0.00006385287,0.9681864,0.00002904259,0.00009640952,0.003168257],"study_design_scores_gemma":[0.00004581253,0.001764003,0.4491035,0.00001582943,0.0001564242,0.005584021,0.0002339486,0.00112299,0.5373501,0.00009845672,0.004511824,0.00001321188],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957515,0.0009998059,0.0008489901,0.00004333751,0.000008686725,0.00002645881,0.001820862,0.00005719427,0.0004430703],"genre_scores_gemma":[0.9967327,0.0002637608,0.0005868126,0.00002892861,0.000003719564,0.0000252437,0.001630358,0.00002247233,0.0007059761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001644842,"threshold_uncertainty_score":0.005502582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03871376592034477,"score_gpt":0.3327544107041853,"score_spread":0.2940406447838406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}