{"id":"W4380302375","doi":"10.1093/neuonc/noad073.313","title":"TRLS-10. ROVER: A PHASE 1/2 STUDY OF AVAPRITINIB IN PEDIATRIC PATIENTS WITH SOLID TUMORS DEPENDENT ON KIT OR PDGFRA SIGNALING","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"PDGFRA; Cancer research; Glioma; Medicine; Stromal cell; GiST","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001774624,0.002017905,0.00244469,0.0004968105,0.0004077494,0.001243483,0.001089816,0.001482958,0.003779984],"category_scores_gemma":[0.0005710519,0.0008539435,0.001495049,0.0004408584,0.0009162277,0.001104512,0.0003682876,0.003845114,0.001514752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001534179,"about_ca_system_score_gemma":0.002272607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002107252,"about_ca_topic_score_gemma":0.004919193,"domain_scores_codex":[0.9994794,0.0002112595,0.00002604474,0.00009940987,0.00005772638,0.0001262824],"domain_scores_gemma":[0.9995541,0.00005105173,0.00007361313,0.00003639613,0.00004621835,0.0002385905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2673212,0.1231932,0.01407073,0.003063024,0.003626164,0.002503963,0.001272826,0.01472942,0.2559784,0.002394043,0.03961726,0.2722298],"study_design_scores_gemma":[0.3583201,0.5673952,0.02006536,0.0001216408,0.001018397,0.003540865,0.0002497754,0.006843987,0.02266155,0.0005380256,0.01912579,0.0001192551],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793674,0.005802914,0.001663492,0.001166051,0.000244966,0.003558784,0.003823474,0.000774508,0.003598331],"genre_scores_gemma":[0.9728439,0.005262618,0.004554338,0.001357149,0.0001363284,0.003351229,0.007308028,0.0002003981,0.004985983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003779984,"threshold_uncertainty_score":0.0126453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0361393782814585,"score_gpt":0.3430252839899051,"score_spread":0.3068859057084465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}