{"id":"W4380302463","doi":"10.1093/neuonc/noad073.212","title":"LGG-02. DRUG-CLASS SPECIFIC GENE-BASED MAPK SENSITIVITY SCORES (MSS) PREDICT SENSITIVITY TO MAPK INHIBITORS AND IDENTIFY IMMUNE INFILTRATION AS PUTATIVE TARGET IN PEDIATRIC LOW-GRADE GLIOMAS","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"MAPK/ERK pathway; Biology; Immune system; Cancer research; Gene; Gene expression; Gene expression profiling; Gene signature; Medicine; Bioinformatics; Immunology; Genetics; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006597709,0.0007958361,0.0007534174,0.001365414,0.0002777128,0.0009767932,0.0006894748,0.0006606911,0.002677006],"category_scores_gemma":[0.001423637,0.0001831293,0.0009792821,0.001315003,0.0002737788,0.0002589384,0.0007547871,0.0004781334,0.001660274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007271982,"about_ca_system_score_gemma":0.0008262285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004944553,"about_ca_topic_score_gemma":0.009997399,"domain_scores_codex":[0.9993621,0.00009795764,0.00004006471,0.0002691672,0.0001447171,0.00008605988],"domain_scores_gemma":[0.9994838,0.0001482037,0.0001213005,0.00007599437,0.00009498091,0.00007574308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003959148,0.00039791,0.6664753,0.002969605,0.001936155,0.0005296013,0.0001475521,0.02048521,0.03991196,0.0009938936,0.1587308,0.1034629],"study_design_scores_gemma":[0.0008597613,0.002120364,0.7156355,0.00046983,0.001667972,0.002358775,0.0003310216,0.05279185,0.03745873,0.00308067,0.183088,0.0001375968],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"dataset","genre_gemma":"empirical","genre_scores_codex":[0.4528144,0.005455407,0.002833141,0.0007030702,0.0001128324,0.0001982051,0.5295711,0.003701884,0.00460995],"genre_scores_gemma":[0.271722,0.001006628,0.006613161,0.0006769226,0.00004444476,0.0002528714,0.717464,0.0001940273,0.002026013],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004944553,"threshold_uncertainty_score":0.009831548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01617576121760463,"score_gpt":0.2890989774877802,"score_spread":0.2729232162701756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}