{"id":"W4380302510","doi":"10.1093/neuonc/noad073.254","title":"MDB-21. THE OTX2-REGULATED ALTERNATIVE SPLICING LANDSCAPE CONTROLS DIFFERENTIATION AND RECONSTITUTES THE DEVELOPMENTAL ORIGINS OF GROUP 3 MEDULLOBLASTOMA","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; McGill University; University of Manitoba; Hospital for Sick Children","funders":"","keywords":"Exon; RNA splicing; Exon skipping; Medulloblastoma; Biology; Alternative splicing; Morpholino; Transcriptome; Gene knockdown; Genetics; RNA; Cancer research; Gene; Molecular biology; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006106892,0.0001324175,0.0001110443,0.0001577269,0.0001604716,0.0002664083,0.0001006185,0.0001291605,0.001425192],"category_scores_gemma":[0.00007027946,0.00007356685,0.0001138969,0.0000933622,0.0001543843,0.00007888376,0.0001785952,0.0002571312,0.0003446596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003402543,"about_ca_system_score_gemma":0.0001610874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001176864,"about_ca_topic_score_gemma":0.00287177,"domain_scores_codex":[0.9999342,0.000005478384,0.000003854036,0.00001765419,0.00002165361,0.00001716677],"domain_scores_gemma":[0.9999479,0.00000588386,0.0000156803,0.000005015436,0.000005006614,0.00002049036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00007167802,0.00000773896,0.001266035,0.00001035066,0.000001998058,0.00005736145,0.00001179571,0.00004241306,0.9977309,0.00006450562,0.00003914088,0.0006960154],"study_design_scores_gemma":[0.0000153939,0.0001533301,0.07305346,0.000007165419,0.00001658804,0.0006743638,0.0001064469,0.001615253,0.9176051,0.00009009679,0.006657859,0.000004933624],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970081,0.0004489059,0.0007640109,0.00003948151,0.000008487743,0.00001129927,0.0006859603,0.00003304141,0.001000709],"genre_scores_gemma":[0.9954287,0.0001831039,0.0005641856,0.00003084505,0.000002118899,0.00001606736,0.001200155,0.00002010287,0.002554752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001425192,"threshold_uncertainty_score":0.004767776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01485475447385752,"score_gpt":0.2750503302383651,"score_spread":0.2601955757645075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}