{"id":"W4380302532","doi":"10.1073/pnas.2219431120","title":"Cross talk between Paneth and tuft cells drives dysbiosis and inflammation in the gut mucosa","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Biochemical Analysis and Sensing Techniques","field":"Nursing","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Institute of Genetics; National Institutes of Health; Laboratoire d'Excellence EpiGenMed; Direction Générale de l’offre de Soins; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Université de Montpellier; Institut National de la Santé et de la Recherche Médicale; Institut National Du Cancer; AgroParisTech; Centre National de la Recherche Scientifique; Ligue Contre le Cancer; Fondation pour la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Tuft; Dysbiosis; Inflammation; Cell biology; Paneth cell; Intestinal mucosa; Biology; Immunology; Medicine; Gut flora; Internal medicine; Small intestine; Engineering","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001554139,0.00006153279,0.0001139119,0.0001442707,0.0001645454,0.00006459124,0.0002965438,0.00007599737,0.000001070062],"category_scores_gemma":[0.0002968968,0.00003445859,0.00003051896,0.0007834199,0.0008086566,0.0002245748,0.0000962959,0.0001192651,2.328207e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009023019,"about_ca_system_score_gemma":0.000002937457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001882131,"about_ca_topic_score_gemma":2.287158e-7,"domain_scores_codex":[0.9989573,0.00001072115,0.0002301753,0.0001640879,0.0005367275,0.0001010257],"domain_scores_gemma":[0.9994698,0.0002304554,0.0001938121,0.000006684397,0.00008449494,0.00001478644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005760141,0.000006388561,0.0452477,0.0000462677,0.000005545921,4.239038e-9,0.0007233291,0.000003935558,0.9492489,0.002084241,0.0003423021,0.002285592],"study_design_scores_gemma":[0.00004784109,0.00001709368,0.3369177,0.00005311767,0.000009517471,0.000001045408,0.0001731994,0.0009261824,0.6155753,0.04616203,0.00007706076,0.00003988477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877003,0.00004102342,2.017498e-7,0.01175275,0.000005386363,0.0000948309,0.000006085772,0.00001609189,0.0003832939],"genre_scores_gemma":[0.9992361,0.00003799449,0.000519623,0.0001357907,0.0000509137,0.000002252646,2.989727e-7,0.000001911787,0.00001513025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3336736,"threshold_uncertainty_score":0.2979529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03990061283020142,"score_gpt":0.324088407854571,"score_spread":0.2841877950243696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}