{"id":"W4380302532","doi":"10.1073/pnas.2219431120","title":"Cross talk between Paneth and tuft cells drives dysbiosis and inflammation in the gut mucosa","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Biochemical Analysis and Sensing Techniques","field":"Nursing","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Institute of Genetics; National Institutes of Health; Laboratoire d'Excellence EpiGenMed; Direction Générale de l’offre de Soins; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Université de Montpellier; Institut National de la Santé et de la Recherche Médicale; Institut National Du Cancer; AgroParisTech; Centre National de la Recherche Scientifique; Ligue Contre le Cancer; Fondation pour la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Tuft; Dysbiosis; Inflammation; Cell biology; Paneth cell; Intestinal mucosa; Biology; Immunology; Medicine; Gut flora; Internal medicine; Small intestine; Engineering","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000238577,0.0002219509,0.0002897785,0.0002885234,0.0001772952,0.0005224305,0.0001294669,0.000315003,0.001063096],"category_scores_gemma":[0.0002437041,0.0001480983,0.0001810699,0.000146883,0.0003326915,0.0004037853,0.0004633763,0.0007312239,0.000176879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001655771,"about_ca_system_score_gemma":0.0001349205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001044246,"about_ca_topic_score_gemma":0.0002674823,"domain_scores_codex":[0.9997806,0.00004046472,0.00001769907,0.00005634056,0.00005441375,0.00005033573],"domain_scores_gemma":[0.9998376,0.00002458859,0.00003526055,0.00002058819,0.00001553383,0.00006636082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002412818,0.00002078352,0.002318333,0.00003931428,0.000005562263,0.0001361383,0.00005168661,0.00002106313,0.9944355,0.0001816574,0.0000168295,0.002531799],"study_design_scores_gemma":[0.00005769712,0.001037667,0.08481786,0.00003887798,0.00005076034,0.001699007,0.0006392561,0.002180955,0.9060031,0.0007501865,0.002710656,0.00001408583],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99613,0.001338251,0.001763052,0.0001021954,0.00002142204,0.00001137543,0.00003880215,0.00002817503,0.0005668083],"genre_scores_gemma":[0.9964617,0.0005129738,0.002051889,0.00007024333,0.00001549144,0.00001446939,0.00005012961,0.000006607615,0.0008165951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001063096,"threshold_uncertainty_score":0.00355643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03990061283020142,"score_gpt":0.324088407854571,"score_spread":0.2841877950243696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}