{"id":"W4380319279","doi":"10.1016/j.healun.2023.06.001","title":"Immunomodulation of the donor lung with CRISPR-mediated activation of IL-10 expression","year":2023,"lang":"en","type":"article","venue":"The Journal of Heart and Lung Transplantation","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; Toronto General Hospital; Toronto Rehabilitation Institute; University of Toronto; University Health Network","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; University Health Network Foundation; Canadian Society of Transplantation; University of Toronto","keywords":"CRISPR; Downregulation and upregulation; Lung; In vivo; Immunology; Immunosuppression; Transplantation; Ex vivo; Biology; Cancer research; Lung transplantation; Cytokine; Medicine; Gene; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002284641,0.00004821856,0.00007183283,0.00003568792,0.00004012724,0.0000031408,0.0000507346,0.00003438874,0.000002913801],"category_scores_gemma":[0.00001082004,0.00002655612,0.00002994266,0.00008931382,0.0000254248,0.000007883289,0.000005830773,0.00004978419,1.072033e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002784525,"about_ca_system_score_gemma":0.00001957678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007807807,"about_ca_topic_score_gemma":0.000004944113,"domain_scores_codex":[0.9995858,0.00004366565,0.0001692049,0.0000395935,0.0001092034,0.0000525278],"domain_scores_gemma":[0.9996933,0.00003486128,0.0001122781,0.00007547806,0.00007157286,0.00001246052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003885119,0.000007138758,0.003401793,0.00007650714,0.00002350536,1.240876e-7,0.0004980392,0.006146137,0.989158,0.000001768282,0.0001702588,0.0001282068],"study_design_scores_gemma":[0.0004220741,0.0001200738,0.1815364,0.0001232175,0.00005469273,0.00002342688,0.0001140025,0.001184625,0.816295,0.000005840045,0.00008889443,0.00003175572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897314,0.000209954,0.009757144,0.0001503759,0.00004527697,0.00008066561,0.000006193579,0.000001919262,0.0000170626],"genre_scores_gemma":[0.9992748,0.0004975432,0.0001329121,0.000008523842,0.00003506735,8.305524e-7,0.00002174335,0.000005500237,0.00002310529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1781346,"threshold_uncertainty_score":0.1082927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005015684283398284,"score_gpt":0.2627902738665811,"score_spread":0.2577745895831828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}