{"id":"W4380354507","doi":"10.1093/neuonc/noad073.037","title":"BIOL-18. NEWLY DEVELOPED REPLICATION REPAIR DEFICIENT (RRD) MOUSE MODELS PROVIDE INSIGHTS INTO MEDULLOBLASTOMA/GLIOMAGENESIS AND RESPONSE TO IMMUNOTHERAPY","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Princess Margaret Cancer Centre; Hospital for Sick Children","funders":"","keywords":"OLIG2; Medulloblastoma; Cancer research; Nestin; Glioma; Biology; Germline; MLH1; Germline mutation; DNA mismatch repair; Mutation; Genetics; Stem cell; Gene; DNA repair; Neural stem cell; Neuroscience; Oligodendrocyte; Myelin; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004932031,0.0008998454,0.0003241381,0.001447893,0.0003754189,0.0006592944,0.0006425186,0.0009752793,0.005655413],"category_scores_gemma":[0.0001174203,0.0005041737,0.0006157514,0.0003084251,0.0005919235,0.0006460075,0.0005456257,0.001787122,0.001960165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006608992,"about_ca_system_score_gemma":0.0004053133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007233191,"about_ca_topic_score_gemma":0.002302864,"domain_scores_codex":[0.9996624,0.00004341629,0.00003993037,0.00009525281,0.00009605391,0.00006299928],"domain_scores_gemma":[0.9997374,0.00001611417,0.0001011894,0.00002447183,0.00002078734,0.000100102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002661253,0.0001140113,0.00063625,0.000136527,0.00001809364,0.0001659066,0.00005673479,0.000131693,0.9904185,0.001985374,0.0006801357,0.00539071],"study_design_scores_gemma":[0.000214771,0.001183993,0.009396544,0.000125317,0.0001099622,0.002030966,0.000134483,0.00210458,0.9182749,0.0008937521,0.06550335,0.00002731668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8819553,0.009356395,0.06450562,0.002618848,0.000646316,0.0006501145,0.01665262,0.003530207,0.02008454],"genre_scores_gemma":[0.8785917,0.007505022,0.04337001,0.0006364465,0.0001309964,0.001218806,0.009664705,0.0006617116,0.05822057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005655413,"threshold_uncertainty_score":0.01891923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04417581247681401,"score_gpt":0.3301377840276562,"score_spread":0.2859619715508422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}