{"id":"W4380355976","doi":"10.1093/neuonc/noad073.175","title":"HGG-26. GENOMIC AND IMMUNE ANALYSIS OF PRIMARY REPLICATION-REPAIR DEFICIENT (RRD) GLIOMAS REVEALS THREE SUBGROUPS WITH DISTINCT DRIVERS AND RESPONSE TO IMMUNOTHERAPY: AN IRRDC REPORT","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Biology; Microsatellite instability; Glioma; Genome instability; ATRX; Cancer research; Genetics; Somatic hypermutation; Mutation; Transcriptome; Chromothripsis; DNA mismatch repair; Gene; Allele; Microsatellite; DNA repair; Gene expression; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001622938,0.0002098981,0.00027024,0.0004934456,0.0002183307,0.000401188,0.0001587876,0.0002117819,0.001587989],"category_scores_gemma":[0.0002858987,0.0001002281,0.0002179067,0.0004120823,0.0002083581,0.0001002438,0.0003409237,0.0001967574,0.0003947912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002191738,"about_ca_system_score_gemma":0.0001389409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009769873,"about_ca_topic_score_gemma":0.001507983,"domain_scores_codex":[0.9998728,0.0000139532,0.000008751216,0.0000540767,0.00001732727,0.00003319543],"domain_scores_gemma":[0.9997713,0.0000302603,0.00005247784,0.00004111129,0.00002907023,0.00007586602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001385898,0.0001068753,0.845205,0.00007686406,0.0001196517,0.001386821,0.000180042,0.0001355462,0.1348024,0.00007709106,0.0005148992,0.01600899],"study_design_scores_gemma":[0.00002762036,0.0004530953,0.9817218,0.000006720446,0.00008436329,0.005328693,0.0002026139,0.0003027104,0.01011124,0.00006885327,0.001686826,0.00000550829],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986545,0.000222455,0.0001763157,0.00001909409,0.000002251582,0.000009856683,0.000596957,0.00001400957,0.0003046608],"genre_scores_gemma":[0.9979146,0.00007364604,0.0002481151,0.00002619562,0.000003960466,0.000008582389,0.001522078,0.000008366175,0.0001944616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001587989,"threshold_uncertainty_score":0.005312324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02305393356631866,"score_gpt":0.3015956650753756,"score_spread":0.2785417315090569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}