{"id":"W4380358406","doi":"10.1093/neuonc/noad073.010","title":"ATRT-10. SINGLE-CELL TRANSCRIPTOME ANALYSIS REVEALS CELLULAR HIERARCHIES AND THERAPEUTIC VULNERABILITIES OF ETMR","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre","funders":"","keywords":"Biology; Transcriptome; SOX2; Neurogenesis; Neural stem cell; Cell cycle; Gene silencing; Population; microRNA; Cell; Cancer research; Stem cell; Progenitor cell; Cell biology; Gene; Genetics; Embryonic stem cell; Gene expression; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002217713,0.0001880178,0.0003170587,0.0002481111,0.0001814203,0.0005045011,0.000173763,0.0002358968,0.001098299],"category_scores_gemma":[0.0002134668,0.0001333873,0.0002997295,0.0002332717,0.0001635829,0.0001549883,0.0001841552,0.0005324899,0.0005741775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002866088,"about_ca_system_score_gemma":0.0002166748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006035187,"about_ca_topic_score_gemma":0.0008076294,"domain_scores_codex":[0.9998168,0.00001557216,0.0000103384,0.0000642724,0.00006115295,0.0000318585],"domain_scores_gemma":[0.999844,0.00003375076,0.00004347982,0.0000205214,0.00002651091,0.00003178574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001009276,0.0000142342,0.001939881,0.00004345097,0.00001121722,0.00006771149,0.00002478696,0.0003449372,0.9941269,0.00008961371,0.0001633584,0.003072869],"study_design_scores_gemma":[0.00002022711,0.0004276666,0.07464018,0.00001746339,0.00006953903,0.001003527,0.0001863497,0.01285945,0.9006551,0.0003001848,0.009800639,0.00001966858],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818848,0.00131838,0.007974307,0.0001519358,0.00003473772,0.0000495217,0.006430878,0.0003236783,0.00183174],"genre_scores_gemma":[0.9832143,0.0006920028,0.00605803,0.0001241316,0.000009613226,0.00008398766,0.007347493,0.0001066932,0.002363761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001098299,"threshold_uncertainty_score":0.003674209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02675373113617198,"score_gpt":0.2609061347252815,"score_spread":0.2341524035891095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}