{"id":"W4380358639","doi":"10.1093/neuonc/noad073.219","title":"LGG-09. CLINICAL ACTIVITY OF PAN-RAF INHIBITOR TOVORAFENIB IN THE REGISTRATIONAL PEDIATRIC LOW-GRADE GLIOMA ARM OF THE PHASE 2 FIREFLY-1 (PNOC026) STUDY","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Adverse effect; Medicine; Glioma; Clinical endpoint; Internal medicine; Phases of clinical research; Clinical trial; Oncology; Surgery; Gastroenterology; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009840872,0.0001899628,0.0006256191,0.0002026116,0.00007531895,0.000007841165,0.0002735372,0.0001796358,0.00003035681],"category_scores_gemma":[0.000942434,0.0001112153,0.0002684785,0.001162183,0.0002040768,0.00004741738,0.0001276037,0.0004490189,0.00001760526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007936992,"about_ca_system_score_gemma":0.0004358679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008204678,"about_ca_topic_score_gemma":0.0002275434,"domain_scores_codex":[0.9971327,0.0008888087,0.0007762598,0.0004018887,0.0005251104,0.0002752306],"domain_scores_gemma":[0.9960039,0.002759409,0.0004488647,0.000615262,0.00009421686,0.00007832021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00160478,0.06042211,0.7867333,0.0001183189,0.0001816787,0.002262733,0.001706267,0.00002441268,0.118673,0.000183963,0.01173975,0.01634966],"study_design_scores_gemma":[0.0184893,0.0104869,0.9375395,0.00002395711,0.000488433,0.0001054338,0.0006577084,0.00011771,0.02889932,0.0001120574,0.002953953,0.0001257964],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905702,0.00006298212,4.994084e-7,0.006860599,0.0006851818,0.001471536,0.00004398641,0.00002932773,0.0002757189],"genre_scores_gemma":[0.9989077,0.00008334156,0.00001270877,0.0002943719,0.0004865724,0.0001749232,0.00001275685,0.00001863357,0.000008966936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1508061,"threshold_uncertainty_score":0.4535227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07688933433642507,"score_gpt":0.4078820938607707,"score_spread":0.3309927595243456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}