{"id":"W4380358639","doi":"10.1093/neuonc/noad073.219","title":"LGG-09. CLINICAL ACTIVITY OF PAN-RAF INHIBITOR TOVORAFENIB IN THE REGISTRATIONAL PEDIATRIC LOW-GRADE GLIOMA ARM OF THE PHASE 2 FIREFLY-1 (PNOC026) STUDY","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Adverse effect; Medicine; Glioma; Clinical endpoint; Internal medicine; Phases of clinical research; Clinical trial; Oncology; Surgery; Gastroenterology; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001481157,0.0008646605,0.001086588,0.0002445681,0.0001750597,0.0008882745,0.0006172295,0.0008784324,0.003756809],"category_scores_gemma":[0.0006313589,0.0002778553,0.0008566252,0.0002557832,0.0004220228,0.00037885,0.0002721725,0.001747037,0.001049694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008047064,"about_ca_system_score_gemma":0.001156572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009459314,"about_ca_topic_score_gemma":0.004452085,"domain_scores_codex":[0.9995133,0.0002699218,0.00001657937,0.00005427525,0.00006017666,0.00008580441],"domain_scores_gemma":[0.9996004,0.00005989402,0.00008384245,0.0000354073,0.00002495059,0.0001955915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5929267,0.02532366,0.03201282,0.001735771,0.002227718,0.00081001,0.0002694447,0.002427613,0.05687773,0.001065614,0.03963149,0.2446915],"study_design_scores_gemma":[0.5243314,0.368874,0.0692633,0.0001928761,0.001201911,0.001115576,0.0001016797,0.002005027,0.008805421,0.0006139218,0.02343945,0.00005556171],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799105,0.00462271,0.0004653198,0.001043092,0.000182342,0.001287777,0.00539697,0.000219403,0.006871857],"genre_scores_gemma":[0.9803134,0.00288613,0.001406463,0.001582514,0.000165136,0.001205837,0.007540284,0.00005427047,0.004846029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003756809,"threshold_uncertainty_score":0.01256782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07688933433642507,"score_gpt":0.4078820938607707,"score_spread":0.3309927595243456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}