{"id":"W4380359043","doi":"10.1093/neuonc/noad073.195","title":"IMMU-08. SALVAGE IMMUNOTHERAPIES FOR REPLICATION REPAIR DEFICIENT (RRD) HIGH-GRADE GLIOMA FAILING ANTI-PD1 MONOTHERAPY: AN IRRDC REPORT","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; Hospital for Sick Children","funders":"","keywords":"Ipilimumab; Medicine; Nivolumab; Immunotherapy; Internal medicine; Progressive disease; Immune checkpoint; Salvage therapy; Oncology; Expanded access; Progression-free survival; Blockade; Surgery; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002960555,0.0006035242,0.000582345,0.0006275926,0.0002536355,0.0009962355,0.0004752029,0.000662234,0.001287197],"category_scores_gemma":[0.001214002,0.0001554475,0.0007889527,0.0004703406,0.0003803217,0.0002766053,0.0003258534,0.0007933306,0.0008099492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007308414,"about_ca_system_score_gemma":0.001187706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008530103,"about_ca_topic_score_gemma":0.0009006874,"domain_scores_codex":[0.9990146,0.0004108427,0.0001438647,0.0001288274,0.0001355167,0.0001663157],"domain_scores_gemma":[0.9990884,0.0002233528,0.0002011084,0.0001673112,0.0001138892,0.0002059564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.03962078,0.01428233,0.1293849,0.001758358,0.001351982,0.01182005,0.0006439182,0.002462082,0.06147355,0.002161393,0.01502357,0.720017],"study_design_scores_gemma":[0.02218221,0.2459739,0.2325416,0.001234171,0.004097737,0.04723942,0.000759853,0.006120244,0.1884918,0.001021595,0.250155,0.0001824409],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9235962,0.039691,0.005812689,0.001888686,0.000382924,0.001196381,0.00347326,0.0003495448,0.02360939],"genre_scores_gemma":[0.9677107,0.01324699,0.006178837,0.002163073,0.0004248249,0.0005320158,0.005731221,0.00006435359,0.003948011],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002960555,"threshold_uncertainty_score":0.01565707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0378756249317001,"score_gpt":0.34134928180455,"score_spread":0.3034736568728499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}