{"id":"W4380359389","doi":"10.1093/neuonc/noad073.061","title":"DIPG-14. PROTEOGENOMICS PROFILING REVEALS ENRICHED NON-HISTONE PROTEIN METHYLTRANSFERASES AS NEW THERAPEUTIC TARGETS IN DIPG","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"","keywords":"Biology; Epigenetics; Histone; Proteome; Histone H3; Transcriptome; Proteomics; Proteogenomics; Methyltransferase; DNA methylation; Methylation; Genetics; Cancer research; Gene expression; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001262661,0.0003352549,0.0003976916,0.0003455071,0.0001421479,0.0002782352,0.0002081779,0.0002641845,0.0009639835],"category_scores_gemma":[0.0001066577,0.0001216128,0.0003090285,0.0003720119,0.0001649811,0.0001414144,0.0002122756,0.0004468941,0.0003146368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003169393,"about_ca_system_score_gemma":0.0002310476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007586497,"about_ca_topic_score_gemma":0.001160073,"domain_scores_codex":[0.9999306,0.000005046063,0.000003329524,0.00001950864,0.00002297851,0.00001842251],"domain_scores_gemma":[0.9999605,0.000003812193,0.00001166492,0.00000408316,0.000008019592,0.00001187436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005166995,0.0000378806,0.003164283,0.000229076,0.00005177659,0.0002036856,0.00001645972,0.0002627519,0.9830168,0.00008545932,0.0005611499,0.01185402],"study_design_scores_gemma":[0.0001035765,0.001082428,0.08948807,0.00002747955,0.0002021503,0.002224191,0.00007250753,0.004232569,0.8863373,0.0004270517,0.01577763,0.00002515929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976233,0.009613572,0.00551055,0.0003500513,0.00005620948,0.0001395692,0.006224113,0.0003744923,0.001498499],"genre_scores_gemma":[0.9818491,0.002796724,0.005737751,0.000278684,0.00001255968,0.00009338413,0.007384081,0.00005711921,0.00179068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009639835,"threshold_uncertainty_score":0.00322485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03884201523732462,"score_gpt":0.3449354287643239,"score_spread":0.3060934135269993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}